BioFINDER

🔬 New work publication in Molecular Psychiatry!
In >2,000 BioFINDER participants, we show that CSF p-tau205 tracks Alzheimer’s disease progression and could contribute to biological staging, emerging later than Aβ42/40 and p-tau217 and closer to neocortical tau pathology.

📢 New preprint from BioFINDER, led by @karlssonlinda1!
We trained a deep learning model to generate synthetic tau-PET 3D scans from more accessible data: structural MRI, plasma p-tau217, and age. medrxiv.org/content/10.648…

New paper in @GreenJournal! We investigated whether future AD dementia can be predicted in individuals with subjective cognitive decline. We found that plasma p-tau217, cognitive testing, and APOE ε4 status accurately identify those at highest risk. neurology.org/doi/pdf/10.121…

New publication in JAMA Neurology! 🧠
In this study, led by @gesalbla, we developed and validated a plasma-based biological staging model for Alzheimer’s disease using two blood biomarkers: %p-tau217 and eMTBR-tau243.
jamanetwork.com/journals/jaman…

New paper in Nature Aging led by PhD student @LuLina000147323! We mapped how APOE ε4 and APOE ε2 shape molecular changes in blood and cerebrospinal fluid across Alzheimer’s disease. nature.com/articles/s4358…