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Truly an honor to give the NIH Director’s WALS lecture today especially as the last speaker under the leadership of @NIHDirector Dr Monica Bertagnolli
Bita Moghaddam بيتا مقدم
@bita137
Professor of Behavioral Neuroscience I Founder of @moghaddamlab | author of KETAMINE mitpress.mit.edu/9780262542241/…
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Recommend this review especially since we have actual data now to support (or refute!) some of the theories here on how psychedelics may influence reward learning and behavioral flexibility
biorxiv.org/content/10.648…
biorxiv.org/content/10.648…
Serotonin biology as a basis for explaining psychedelic drug action - we learned a lot writing this review for @CurrentBiologyView quoted post on X
cell.com/current-biolog…
We know a good deal about serotonin, which should teach us how psychedelics work. But what’s the same? What’s different? 🤔
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Please check out my futuristic opinion piece in
@JAMAPsych
"specific treatments for schizophrenia that are tailored to target symptoms at different developmental stages are no longer the stuff of science fiction, but instead are realistic future goals"
jamanetwork.com/journals/jamap…
@JAMAPsych
"specific treatments for schizophrenia that are tailored to target symptoms at different developmental stages are no longer the stuff of science fiction, but instead are realistic future goals"
jamanetwork.com/journals/jamap…
jamanetwork.com Updating Treatment Goals for Schizophrenia This article discusses research providing renewed reasons to revisit the utility of glutamatergic drugs for treating schizophrenia. It is indeed important to consider the 60's &70's papers that showed adverse effects of unsupervised LSD use (e.g. sciencedirect.com/science/articl… ) However, if there was adequate clinical supervision, the incidence of such reactions were super low (e.g. Malleson, Br J Psychiat 118:229)
Psychedelics have sordid history in psychiatry. By mid 1960’s, LSD, psilocybin production for ”therapeutic purposes” was halted because of adverse events. Only when intense sessions pre-, during, post-drug dosing were used and most volunteers excluded, did safety margin improve.View quoted post on X
Enjoyed giving this talk on the effects of psilocybin and aversive learning. Some of the new data should be ready for preprint soon
Session 4 explored the system-level integration of weighing reward and punishment, featuring fascinating talks from Drs. Moghaddam, Baunez, Carnicella, and Granwald.View quoted post on X
