Biton Lab

@bitonslab

Understanding mucosal tissue dynamics

UK building Weizmann Institute weizmann.ac.il/Biological_Reg… Joined November 2019

80 Following 250 Followers 35 Posts

Latest posts 5

📢We are excited to share our latest bioRxiv preprint from the Biton Lab!

We identify CD45 as a tuft cell–intrinsic negative regulator of intestinal type 2 immunity

We'd love to hear your thoughts and feedback!

🔗 doi.org/10.64898/2026.…

#bioRxiv #MucosalImmunity #TuftCells

Biton Lab @bitonslab May 13

🧵 It’s out 📑
What happens when Salmonella reaches the intestinal crypt, not just the surface epithelium, but the specialized cells that maintain and defend the tissue?
Our paper follows bacterial invasion at single-cell resolution

nature.com/articles/s4159…
@NatImmunol
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www.nature.com An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella... Nature Immunology - Salmonella-invaded intestinal stem cells activate an inflammasome-driven differentiation program toward antimicrobial Paneth cells, revealing a protective stem cell defense...

Biton Lab @bitonslab May 8

Excited to share our new @biorxivpreprint from the lab!
We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense.
biorxiv.org/content/10.648…

Biton Lab @bitonslab Mar 21

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
doi.org/10.64898/2026.…

Biton Lab @bitonslab Jun 9, 2025

Excited to share our latest preprint with @Sagi_Lab on @biorxivpreprint!
The ECM remembers inflammation—forming a scarred niche that reprograms stem cells and drives chronic disease.
The ECM isn't passive—it instructs.
🔗biorxiv.org/content/10.110…
#IBD #ECM #StemCells #Inflammation

www.biorxiv.org Persistent ECM Scarring Reprograms Intestinal Stem Cells to Drive Chronic Inflammation Tissue regeneration is conventionally viewed as a return to homeostasis. Here, we uncover that the extracellular matrix (ECM) in the colon undergoes a lasting pathological reprogramming following...