Bruce Vallance

@BruceVallance

Moved to Bluesky! @brucevallance.bsky.social
IBD, Bacterial Pathogens and Mucosal Immunology at BC Children's Hospital and UBC. Foodie, Fisherman and Father.

Vancouver, BC Joined February 2014

284 Following 584 Followers 136 Posts

Latest posts 5

Bruce Vallance @BruceVallance Jun 2, 2025

🚨 We’re featured in @CBCNews!
Our team is using organoids to study how microbes interact with the gut mucus layer, and how this relationship impacts diseases like IBD 💩🔬
📰 Read the full story: cbc.ca/news/health/fe…
#Microbiome #GutHealth #Organoids #IBD

www.cbc.ca How much does your gut health impact your overall health? A lot, doctors say | CBC News Doctors are tapping into to the emerging field of the gut microbiome to try to treat some diseases differently.

Bruce Vallance @BruceVallance May 8, 2025

New paper led by @chenyan485! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. pmc.ncbi.nlm.nih.gov/articles/PMC12…
🧫🦠

pmc.ncbi.nlm.nih.gov Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an... Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined....

Bruce Vallance @BruceVallance Oct 8, 2021

Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells pnas.org/content/118/41…

Bruce Vallance @BruceVallance Dec 21, 2020

They call it Research Chair because the only science henceforth will be conducted from a chair... Hard to believe this was 16 years ago.
universityaffairs.ca/news/news-arti…

Bruce Vallance @BruceVallance Dec 1, 2020

Our recent collaboration using an Ulcerative Colitis-associated pathobiont to create a new murine IBD model - published by Gut Microbes @JoannieAllaire @hongbing_yu @ElseBosman doi.org/10.1080/194909…
#IBD #guthealth #bcchr