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Blake Byers

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@byersblake

Cofounder @Newlimit to extend our lifespans. Investor in early stage founders — 10 IPOs and counting. @Stanford bioengineering PhD.
San Francisco, CA blakebyers.com Joined July 2011
360 Following 21K Followers 706 Posts

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Blake Byers Verified account @byersblake
This is the best ground-up description I’ve seen for why many incumbents won’t make the AI transition (primarily those that lack inherent network effect or data exclusivity). You can’t graft this process onto existing teams — the humans can’t keep up with volume and context.
jacob Verified account @jsnnsa Oct 29
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Blake Byers Verified account @byersblake
ASI orchestration layer for professional healthcare being built. We are roughly already at the point where it’s malpractice to treat a patient without using an AI copilot.
OpenEvidence @OpenEvidence Oct 22
Over 85% of oncologists at Memorial Sloan Kettering Cancer Center use OpenEvidence.

Together, @MSKCancerCenter and OpenEvidence have built OncoKB, MSK’s expert interpretation of a tumor’s genetics, directly into OpenEvidence, putting it in the hands of oncologists across the United States.

As Dr. Anaeze Offodile puts it: “Our mission is to end cancer for life.” As of today, we are widening OncoKB’s reach so that patients everywhere benefit from the same rigor as patients at MSK. Watch the story.
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Blake Byers Verified account @byersblake
Over the summer, we achieved more drug development milestones than in the rest of @newlimit history. We scaled our manufacturing processes, ran our first large animal model studies, and engaged productively with regulators. Our pipeline of reprogramming payloads continued to grow, hitting new all time highs for both the quality of our best payloads and the quantity of payloads we explored.

>2X stronger regenerative rescue in old hepatocytes

+2 payloads rescue multiple functions in old hepatocytes

+8 payloads restore function in old endothelial cells, +5 in hepatocytes

314X scale up of therapeutic manufacturing, 13X quality improvement

2.5X improvement in endothelial cell age prediction accuracy

>5000 payloads tested (during just the summer) for effects on cell age (all time high!)

5X improvement in data efficiency from transfer learning
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Blake Byers Verified account @byersblake
Please be true
Nick Verified account @nickcammarata Oct 15
interpretability might be the most important scientific problem in the world right now, as I don't think we can solve alignment if we don't know what we're building. I think I have good news about it. I co-authored early work in mechanistic interpretability at OpenAI and came away pessimistic, because neural networks appeared to fold into arbitrary tangled knots. years later, I started openai's first large-scale automated interpretability project, finding about 2% of neurons legible with the primitive tools we had

with modern agentic tools and a much closer look, the picture looks totally different. the vast majority in models up to trillions of parameters are legible, and their circuits beautiful. many famous examples of tangled neurons turned out to be misunderstood. The roadblocks I expected mostly aren't there. I now think ambitious interpretability will be solved by the time we need it most, and possibly quite soon, as automated scientists keep improving. it may be a bitter lesson for interpretability: the simple thing, at absurd scale, works

already-clean.goodfire.com
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