Centre for Medicines Discovery

@CmdOxford

A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.

Oxford cmd.ox.ac.uk Joined July 2020

59 Following 437 Followers 105 Posts

Latest posts 5

Centre for Medicines Discovery @CmdOxford Aug 21

A New Layer of Control for a Decades-Old Leukemia Drug ndm.ox.ac.uk/news/a-new-lay…

www.ndm.ox.ac.uk A New Layer of Control for a Decades-Old Leukemia Drug How cells respond to the leukemia drug 6-thioguanine still holds surprises: A new study, led jointly by researchers from CeMM and the University of Oxford identifies NUDT5 as an unexpected regulator...

Centre for Medicines Discovery @CmdOxford Sep 2, 2024

Revealing Cationic Amino acid Transporter 1 (CAT1) selectivity and binding to Friend Murine Leukemia Virus. Collab of @mingda_ye, @DavidBSauer, @BenediktKessler, @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, and @im2pact_project

doi.org/10.21203/rs.3.…

www.researchsquare.com Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus... Arginine, lysine, and ornithine are critical to protein structure and function, the urea cycle, and intracellular signaling. These cationic amino acids are imported by several membrane transporters,...

Centre for Medicines Discovery @CmdOxford Jul 9, 2024

The Bullock group at @CmdOxford and Alison Axtman at @thesgconline report the first chemical probe for the CDKL2 kinase providing an important reagent to interrogate CDKL2-dependent biology. pubs.acs.org/doi/10.1021/ac…

Centre for Medicines Discovery @CmdOxford Jun 4, 2024

Donna Di Rienzo, a DPhil student at the ARUK ODDI is the recipient of an ARUK Thames Valley Pilot Project Award to discover novel substrates of the E3 ligase IDOL, which is implicated in lipid uptake in the brain.
#ResearchGrant #ARUK #ThamesValley #Collaboration #PilotProject

Centre for Medicines Discovery @CmdOxford Apr 30, 2024

Ubiquitin C-terminal hydrolase UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia.