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Constantin Ahlmann-Eltze (@const-ae.bsky.social)

@const_ae

Postdoc at UCL with @JL_Reading. Previously at EMBL working with @wolfgangkhuber. Biostats, R, cancer immunology
Find me on 🦋 at const-ae.bsky.social
London github.com/const-ae Joined December 2010
674 Following 1.1K Followers 238 Posts

Latest posts 5

Constantin Ahlmann-Eltze (@const-ae.bsky.social) @const_ae
For the Monday morning crowds :)

Also, take a look at my blog post, in which I compress the full lemur package into 100 lines of code and explain the core algorithm.

const-ae.name/post/2025-01-0…
const-ae.name LEMUR simplified | const-ae A simplified implementation of the LEMUR algorithm.
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳

nature.com/articles/s4158…

LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.

Some highlights⬇️
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Constantin Ahlmann-Eltze (@const-ae.bsky.social) @const_ae
Great thread by Anshul, one of the pioneers of deep learning for biology, summarizing our preprint!
Anshul Kundaje @anshulkundaje Sep 21, 2024
biorxiv.org/content/10.110…

Nice benchmark of single cell "foundation models" (scGPT, scFoundation) and GEARS (a GNN model) further hyped as "virtual cell models" against linear baselines on perturbation prediction.

Long-story short: they can't beat the linear baselines. 1/
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