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Cosmin Tudose

@cosmint_

cosmintudose.bsky.social
Joined July 2020
398 Following 195 Followers 115 Posts

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Cosmin Tudose @cosmint_
Pleased that the 2nd part of my PhD in now available as a preprint! Here, we investigated the epigenomic and transcriptomic changes occurring upon PRC2 depletion in AML cells. biorxiv.org/content/10.110…. A thread🧵1/17
www.biorxiv.org Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute... Background Polycomb Repressive Complex 2 (PRC2) modulates chromatin accessibility and architecture to direct tissue-specific gene expression. PRC2 function is frequently altered in cancer by loss-o...
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Cosmin Tudose @cosmint_
Many thanks to my supervisors @jbond2019 and @colmr, to everyone in @sysbioire and to the @GenomicsCRT! :)
Systems Biology Ire @sysbioire Nov 20, 2024
Congratulations to Cosmin Tudose on passing his viva yesterday! 🥂🎉

Cosmin is co-supervised by @colmr & @jbond2019 funded by @GenomicsCRT. Thesis title: "Defining molecular vulnerabilities in childhood leukaemia through biological network analysis".

Well done @cosmint_! #viva
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Cosmin Tudose @cosmint_
Delighted that our paper is now out in NAR Cancer! Making use of CRISPR screens @CancerDepMap we systematically evaluated the ability of gene regulatory networks (GRNs) to identify genetic dependencies in cancer! A short thread on what we found 🧵1/9 academic.oup.com/narcancer/arti…
academic.oup.com Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network... Abstract. Gene regulatory networks (GRNs) are often deregulated in tumor cells, resulting in altered transcriptional programs that facilitate tumor growth.
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Cosmin Tudose @cosmint_
Gene regulatory networks (GRNs) are used to identify vulnerabilities in cancer, but it's unclear how good they are at this. Here, we used CRISPR screens to systematically evaluate the ability of GRNs to identify genetic dependencies in cancer. biorxiv.org/content/10.110… Thread: 1/16
www.biorxiv.org Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network... Gene regulatory networks (GRNs) are often deregulated in tumor cells, resulting in altered transcriptional programs that facilitate tumor growth. These altered networks may make tumor cells vulnera...