Prof Chris P Gale

Clinical Lead for #MINAP , the largest continuous collection single healthcare system #heartattack registry.

#plozasiran #hypertriglyceridaemia

▶️ #Arrowhead reports pooled SHASTA 3 & 4 data at #AHA26 (757 adults, severe HTG; RCTs)

Plozasiran 25 mg 3 monthly cut the rate of adjudicated acute #pancreatitis events by 78% vs placebo over 12 months (no CI given)

ir.arrowheadpharma.com/news-releases/…

🚁 ECMO to the scene?

#OnScene @NEJM

Adults ≤50 y, refractory out of hospital #cardiacarrest:

ECPR capable vs conventional HEMS, non-randomised

discharge survival 40% vs 20% (OR 2.72, 95% CI 1.59 to 4.66);

favourable 6 mo neuro outcome 36% vs 13%;

adverse events 32 vs 11.

#hypertension #MedEd

The 2024 ESC guideline diagnoses #hypertension at:

office BP ≥140/90 mmHg;
home BP ≥135/85 mmHg; or
24 h ambulatory BP ≥130/80 mmHg.

Measure seated after 5 min rest with a validated device & ideally confirm with home/ambulatory readings #cardiotwitter

ISCHEMIA CKD EXTEND RCT @AHAScience

In advanced #CKD, invasive first care did not extend life

In 777 patients with moderate or severe ischaemia, 8 year mortality was 57.4% invasive vs 56.8% conservative (AHR 1.05, 95% CI 0.87 to 1.28).

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