Daniel Bauer

@danielevanbauer

pediatric hematologist, molecular biologist, genome editor, red sox fan, family man

Joined September 2012

1.9K Following 2K Followers 515 Posts

Latest posts 5

IGF2BP1 revealed as a double agent* hemoglobin switcher! How this heterochronic RBP both inhibits BCL11A (thru HIC2) & directly binds + supports the fetal globin transcript: ashpublications.org/blood/article-… Led by fantastic Steve Coyne. *Scott Peslak commentary: ashpublications.org/blood/article/…

ashpublications.org Direct and indirect regulation of fetal globin transcript by the RNA-binding protein IGF2BP1 Key PointsThe RBP regulates fetal hemoglobin directly through posttranscriptional control and indirectly via BCL11A.IGF2BP1 binding to a stop codon–proxima

Daniel Bauer @danielevanbauer Sep 19

Very proud and grateful to be part of the journey! Fantastic job by @BasheerBecerra, sky is limit! A joy to share this with Luca!

Luca Pinello @lucapinello Sep 19

Very proud of @BasheerBecerra , who defended his PhD yesterday. He came in with no background in CRISPR genome editing and leaves as a true expert in dissecting regulatory elements, combining experimental and computational approaches in a way very few people can.

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Daniel Bauer @danielevanbauer Sep 16

Inspired by Gibson cloning, we describe prime assembly, now published, for in cellulo targeted integration of gene-sized DNA fragments using prime editing. nature.com/articles/s4158…

www.nature.com Targeted genomic integration and rearrangement using prime assembly Nature - Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle progression, and supports exon recoding,...

Daniel Bauer @danielevanbauer Mar 27

In this piece, my mentor Stu Orkin and I (1) marvel at prime editing—discovery to disease correction for 2 patients after just 6 yr—wow Liu, Anzalone, Gori, Malech et al! & (2) consider the challenges to deliver genetic medicine’s promise for 2^n patients nejm.org/doi/full/10.10…

www.nejm.org Genetic Medicine — Primed and Ready | NEJM Immunodeficiency chronic granulomatous disease (CGD) is a rare disorder characterized by defects in a multiprotein complex that generates superoxide in phagocytic cells.1 Recurrent infections and f...

Daniel Bauer @danielevanbauer May 29, 2024

We were inspired by @KajasteLab uncovering host factors that limit genetic engineering in HSCs. Awesome to converge on manipulating nucleotides for RT based gene therapy of quiescent cells.