Dave Boucher

@dave_boucher

Protease signalling, cell death and innate immunity. Reader @biologyatyork @YBRI_UoY. He/him proteaseinimmunity.Bsky.social Boucherlab.org

York, England Joined July 2016

1.1K Following 1.5K Followers 2.5K Posts

Latest posts 5

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Dave Boucher @dave_boucher Aug 3, 2025

New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-…

www.jbc.org 10 things you wish you knew about inflammatory caspases: A holistic review of their biochemistry,... Caspases are a family of cysteine proteases conserved across all metazoa which play critical functions that range from cell death, inflammation, and cellular differentiation. Caspases cleave a subset...

Dave Boucher @dave_boucher Apr 29

Happy #dayofImmnology! We work hard to understand how the human innate immune system protected you against infection ! Thanks to @UKRI_News @BBSRC and @mrc to support our research and the development of novel therapies @YBRI_UoY @BiologyatYork

Dave Boucher @dave_boucher Nov 10, 2025

Three PhD positions open in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or shared it with curious and motivated prospective PhD students: findaphd.com/phds/?Keywords… @BBSRC @YBRI_UoY @BiologyatYork

www.findaphd.com dave boucherare PhD Projects, Programmes & Scholarships

Dave Boucher @dave_boucher Nov 3, 2025

New preprint from the lab from PhD student Seb Grant. Started as a summer side project and developed into an exciting story.
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling. biorxiv.org/content/10.110…

www.biorxiv.org Evolution of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and...

Dave Boucher @dave_boucher Oct 21, 2025

New pre-print from the lab: Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer (NK) cells. biorxiv.org/content/10.110…
@BiologyatYork @YBRI_UoY @The_MRC

www.biorxiv.org Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer cells Inflammasomes are critical in rapidly responding to infections and tissue damage, with current paradigms centred on macrophages and epithelial cells. Natural Killer (NK) cells are innate lymphoid...