Why are mutations in the GBA gene the most common cause of inherited Parkinson's disease? Sheng-Han Kuo, Inmaculada Tasset, Ana Maria Cuervo and team may have figured it out... science.org/doi/10.1126/sc…
www.science.org Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated... Parkinson’s disease–related mutations in β-glucocerebrosidase interfere with selective degradation of α-synuclein by lysosomes. 
