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drtarsh
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MD FRCP MRCGP ICOS-Certified Cardio-Oncologist @RoyalBrompton/Primary Care Physician/@ProstateUKProfs Clinical Champion. #CardioOnc #JACCCardioOnc/Views my own
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A huge step forward in personalised cancer care.Warmest congratulations to Professor Georgina Long and the entire INTerpath-001 team on these exciting phase III results presented at ESMO in Madrid.
How is the vaccine personalised? Scientists compare the patient’s tumour DNA with their normal DNA to identify cancer-specific changes. These inform a bespoke mRNA vaccine encoding up to 34 tumour-specific targets, designed to help T cells recognise and attack that patient’s cancer.
This is what makes these results so compelling: treatment designed around an individual cancer’s molecular signature, translating into meaningful clinical benefit. Eagerly awaiting the cardiac safety data in the full publication in @NEJM in November.
@OncBrothers @HanCardiomd
#ESMO26 #PersonalisedMedicine #CancerVaccines #Melanoma #PrecisionOncology #CardioOncology
How is the vaccine personalised? Scientists compare the patient’s tumour DNA with their normal DNA to identify cancer-specific changes. These inform a bespoke mRNA vaccine encoding up to 34 tumour-specific targets, designed to help T cells recognise and attack that patient’s cancer.
This is what makes these results so compelling: treatment designed around an individual cancer’s molecular signature, translating into meaningful clinical benefit. Eagerly awaiting the cardiac safety data in the full publication in @NEJM in November.
@OncBrothers @HanCardiomd
#ESMO26 #PersonalisedMedicine #CancerVaccines #Melanoma #PrecisionOncology #CardioOncology
It was a great honour to present the results of the phase 3 INTerpath-001 clinical trial at the #ESMO26 Congress in Madrid.
This international trial included 1137 patients, across 157 sites, whose melanoma had been surgically removed, but who were at very high risk of it returning. The trial showed adding #intismeran autogene, an mRNA based individualised neoantigen therapy, to pembrolizumab reduced the risk of recurrence or death by 42%.
This is the first phase 3 study to show that a treatment built from the unique ‘fingerprint’ of a patient’s own tumour can reduce the risk of recurrence or death from cancer. That fingerprint is read by sequencing the tumour, then a ‘wanted poster’ of the cancer is made as mRNA, showing the immune system exactly what to look for and attack. Having succeeded in melanoma, this proof of concept could mark the beginning of a foundational shift in how we treat cancer.
Read more >melanoma.org.au/news/personali…
A huge thank you to all patients and teams involved.
@myESMO @Sydney_Uni @syd_health @Science_Academy @AAHMS_health @FulbrightAUS @NthSydHealth @ausoftheyearView quoted post on X
@avirupguha on stage now at #GCOS2026 highlighting the perils of cardiovascular risk in prostate cancer
@ICOSociety #cardiooncology #cancercare
@ICOSociety #cardiooncology #cancercare
An inspiring evening at the British Ambassador’s Residence in Washington, DC bringing together clinicians, researchers, advocates and policymakers united by a shared mission: ensuring cardiovascular health is central to every stage of cancer care.
Grateful to Sir Christian Turner and colleagues for hosting the Royal Brompton Hospital Cardio-Oncology reception, and proud to mark the forthcoming @TheLancet Group Cardio-Oncology Series ahead of #GCOS2026.
As cancer survival improves, cardiotoxicity prevention, earlier detection and lifelong cardiovascular care must no longer be an afterthought, they must be built into cancer care by design.
#CardioOncology #Cardiology #Oncology #globalhealth #healthcareinnovation
Grateful to Sir Christian Turner and colleagues for hosting the Royal Brompton Hospital Cardio-Oncology reception, and proud to mark the forthcoming @TheLancet Group Cardio-Oncology Series ahead of #GCOS2026.
As cancer survival improves, cardiotoxicity prevention, earlier detection and lifelong cardiovascular care must no longer be an afterthought, they must be built into cancer care by design.
#CardioOncology #Cardiology #Oncology #globalhealth #healthcareinnovation
Aurora, my new robot AI friend who is here to help me find the stage on which I am a discussant! The future is here - thank you Aurora #Ai #robotics #cardiology #oncology @ESCsocialmedia
