@eLife
elifesciences.org Synaptic vesicle undocking induces low-frequency depression Low-frequency depression, an understudied form of synaptic plasticity, is proposed to reflect a reorganization of synaptic vesicles inside the readily releasable pool. elifesciences.org Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic... Glutamine drives its own synthetase to assemble into inhibitory filaments, linking product concentration directly to a conformational switch that gates the active site. 
elifesciences.org Synaptic connectome of a neurosecretory network in the Drosophila brain Connectome-level analysis of the Drosophila neuroendocrine system reveals the organizational logic by which the brain integrates sensory information to regulate hormonal signaling. elifesciences.org Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three... Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery. elifesciences.org Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development Genetic and functional analyses identify SVEP1 as an extracellular matrix regulator that coordinates airway branching, smooth muscle differentiation, and alveolar maturation during lung development. 