@fleet_dj
We show that 3DFlex learns multiple dimensions of flexibility in a tri-snRNP spliceosome complex, while maintaining detail in secondary structure elements that move 20Å+. On TRPV1 ion channel data, 3DFlex learns two kinds of coordinated bending of the soluble domains:
3/View quoted post on X
www.biorxiv.org 3D Flexible Refinement: Structure and Motion of Flexible Proteins from Cryo-EM Single particle cryo-EM excels in determining static structures of biological macromolecules such as proteins. However, many proteins are dynamic, with their motion inherently linked to their... Today we announce the public release of #cryoSPARC v3.0 + #cryoSPARC Live:
Seamless real-time 2D+3D #cryoEM processing is now available for everyone! 🚀
We've redesigned+optimized Live and v3.0 includes new nonuniform & helical refinement, CUDA11 + more: cryosparc.com/liveView quoted post on X
