Samya

Ambeed Inc Verified account @ambeedinfo · Aug 4

🎉 𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐃𝐚𝐯𝐢𝐝 𝐂. 𝐏𝐨𝐰𝐞𝐫𝐬, 𝐒𝐚𝐦𝐲𝐚 𝐒𝐚𝐦𝐚𝐧𝐭𝐚, 𝐋𝐚𝐮𝐯 𝐏𝐚𝐭𝐞𝐥, 𝐃𝐢𝐲𝐚𝐬𝐡𝐚 𝐌𝐚𝐧𝐧𝐚, 𝐚𝐧𝐝 𝐌𝐞𝐥𝐢𝐬𝐬𝐚 𝐎𝐣𝐞𝐝𝐚 𝐨𝐧 𝐭𝐡𝐞𝐢𝐫 𝐧𝐞𝐰 𝐉𝐀𝐂𝐒 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: “𝐁𝐚𝐬𝐞-𝐅𝐫𝐞𝐞 𝐂-𝐍 𝐂𝐫𝐨𝐬𝐬-𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐩𝐡𝐢𝐥𝐞 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠”!

📖 pubs.acs.org/jacsat/article…

🔬 This study introduces a nickel-catalyzed base-free C-N cross-electrophile coupling (XEC) strategy that enables efficient C-N bond formation by coupling electrophilic carbon and nitrogen partners under mild conditions.

🔹 A philicity-mismatched Ni-catalyzed C-N cross-electrophile coupling was developed using electrophilic carbon and nitrogen precursors, eliminating the need for basic additives.

🔹 The method exhibits broad functional group tolerance, including excellent compatibility with base-sensitive substrates and late-stage functionalization.

🔹 Electrophilic nitrogen precursors can be readily prepared from diverse starting materials, including C-H bonds and olefins.

🔹 A two-step, one-pot N-phenothiazination/C-N XEC sequence enables the efficient functionalization of amine-containing bioactive molecules and the synthesis of designer secondary, tertiary, and unsymmetrical diamines.

🔹 Mechanistic studies support a Ni(II)-aryl-amido intermediate as the key species responsible for promoting cross-selectivity while suppressing homocoupling.

🐝 We are pleased to see that 4,4'-di-tert-butyl-2,2'-bipyridine, a key ligand used in this study, was sourced from AmBeed.

𝗧𝗿𝘆 𝗔𝗺𝗕𝗲𝗲𝗱’𝘀 𝗯𝗶𝗽𝘆𝗿𝗶𝗱𝗶𝗻𝗲 𝗹𝗶𝗴𝗮𝗻𝗱𝘀 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵！

ambeed.com/search/Structu…

#AmBeed #JACS #OrganicChemistry #CrossElectrophileCoupling #NickelCatalysis #CNCoupling #Bipyridine #ResearchTools #BuildingBlocks #Paper #Chemistry

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Powers Lab @Powers_Lab · Jul 31

We are excited to disclose our new work towards base-free nitrogen-centered radical XEC, now live at @J_A_C_S . Congratulations to @iamsamya96 , @LauvPatel , @mishti_2906, and Melissa for their hardwork and efforts!
doi.org/10.1021/jacs.6…

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