Journal of Allergy and Clinical Immunology

How does B-cell dysregulation contribute to immune manifestations in multisystem inflammatory syndrome in children? Read on for a systemic evaluation of B-cell subsets, autoantibodies, and correlations between immune phenotypes and clinical parameters. bit.ly/4invlLp

A recent study has shown that IgE-mediated activation of human mast cells leads to production of resolvin D1. Do human cord blood-derived mast cells exposed to docosahexaenoic acid produce other specialized proresolving lipid mediators as well? bit.ly/3VS4Dlk

Persistent symptoms following SARS-CoV-2 infection, termed long COVID, impose substantial burdens. Could blood multi-omics profiles help identify patients with immune-hematopoietic disease features for biomarker-based clinical stratification? bit.ly/4hOPEkT

A subset of group 2 innate lymphoid cells (ILC2s) that express KIT displays increased phenotypic plasticity and has been linked to severe asthma and psoriasis. What molecular mechanisms promote a KIT+ ILC2 state? A study’s findings shed new light. bit.ly/4BriDmD

New findings identify SMURF2 as a critical positive regulator of IgE-FcεRI-mediated mast cell activation and a key contributor to allergic disease pathogenesis. SMURF2 may offer a potential diagnostic marker and treatment target. bit.ly/4ezHhr3