Bull Group Chemistry

@jamesabull

Organic Chemistry Research Group at Imperial College London. Synthesis; Catalysis; Heterocycles. Updates on group news and papers. Account run by JAB

Imperial College imperial.ac.uk/people/j.bull Joined June 2009

680 Following 3.2K Followers 569 Posts

Latest posts 5

Bull Group Chemistry @jamesabull Jun 12

Iron-Catalyzed Friedel–Crafts Reactions of Unactivated 3-Aryl-Oxetanols Exploiting HFIP Stabilization of Carbocations | The Journal of Organic Chemistry pubs.acs.org/doi/10.1021/ac…

pubs.acs.org Iron-Catalyzed Friedel–Crafts Reactions of Unactivated 3-Aryl-Oxetanols Exploiting HFIP Stabiliza... Abstract. Robust methods to access 3,3-disubstituted oxetanes are desired due to the attractive physicochemical properties offered by the polar 4-membered

Bull Group Chemistry @jamesabull Feb 10

Do Amino-Oxetanes Resemble Amides? A Matched Molecular Pairs Property and Structural Comparison | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

pubs.acs.org Do Amino-Oxetanes Resemble Amides? A Matched Molecular Pairs Property and Structural Comparison Abstract. Oxetanes display properties comparable to ketone carbonyl groups and are increasingly explored as bioisosteres. However, does the comparison hold

Bull Group Chemistry @jamesabull Nov 12, 2025

Our latest work on the synthesis of heterocyclic fragments out now:
Regio‐ and Stereocontrolled‐Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C‐H Arylation
doi.org/10.1002/chem.2…

Bull Group Chemistry @jamesabull Sep 2, 2025

Do Amino-Oxetanes Resemble Amides?
Check out our Matched Molecular Pairs study in @ChemRxiv comparing properties and structure.
Congrats @hikaruishikura and coworkers, in collaboration with Pfizer.
doi.org/10.26434/chemr…

Bull Group Chemistry @jamesabull Sep 2, 2025

As asymmetric sulfur(VI) derivatives become more prevalent in the chemical sciences, especially in aza-derivatives, sulfoximines, sulfonimidamides, we have reviewed "The stereochemistry of substitution at S(VI)"
doi.org/10.1039/D5QO01…