Joshua Meier (@joshim5)

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Frontier drug discovery programs require frontier capabilities. Today, we’re excited to share that BMS will be using Chai’s models to support the discovery of new therapeutics. Since rolling out Chai-3 to partners at the start of this year, we’ve partnered with @EliLillyandCo, @Novartis, @Pfizer, @argenxglobal, and now @BMSnews. Many of the world’s leading biopharma companies are now using our models to go after diseases.

Scientific discovery is the domain where access to frontier AI matters the most. At @ChaiDiscovery, we’ve seen first hand how our latest model generations can make the difference between discovering a molecule and not. We’re excited to work with @BMSnews to break new ground in medicine and science.

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Joshua Meier @joshim5 3d

Today we’re announcing a collaboration with @Roche, a leader in AI-driven drug discovery.

Roche will apply @chaidiscovery's platform to help accelerate discovery programs across a number of targets in its therapeutic areas.

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Joshua Meier @joshim5 Oct 9

Drug discovery is where frontier AI can matter the most.

Today we're announcing @Chaidiscovery’s collaboration with @GSK, following a successful wet-lab evaluation of our models. Using Chai-3, @GSK found binders to every target tested.

AI is entering its proof-point phase.

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Joshua Meier @joshim5 Aug 4

Our bet from day one: this is how most future drugs are going to be discovered.

My co-founder @Mattmcpartlon1 and I sat down with @gradypb from @sequoia to talk about how drug discovery is becoming an engineering discipline

Pat Grady Verified account @gradypb Aug 4

To date, finding a drug has been a process of guess & check… screening millions of molecules hoping one binds.

@chaidiscovery is changing the paradigm… describe the molecule you want, and the model designs it.

@joshim5 and @Mattmcpartlon1 took antibody hit rates from roughly 1 in 1,000 to 1 in 7. That's the jump from search to engineering.

On this episode of Training Data, they get into where the field actually is, why 2024 was the moment to start, what drug discovery looks like when the computer does the design, and more.

00:00 Introduction
01:52 From Discovery to Design
03:25 Protein AI Breakthroughs Timeline
06:04 Why Start in 2024
10:13 Diffusion Models Intuition
11:41 Building the Avengers Team
15:22 Hit Rates and Scaling Laws
25:01 Molecular CAD Vision
25:24 Faster Design Loops
26:32 Future Drug Discovery
28:37 Platform Business Model
31:14 Partnering Reality Check
33:44 Data Flywheel Explained
37:16 Staying Ahead at Scale
39:44 Culture and What's Next

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Joshua Meier @joshim5 Jul 15

Every week at @ChaiDiscovery brings new model capabilities, product releases, and successful lab results. Our partnership announcements offer a glimpse into that momentum.

Excited to work with team @ArgenxGlobal to advance their antibody programs.

Chai Discovery Verified account @chaidiscovery Jul 15

We’re delighted to announce our third agreement this week, this time a collaboration with @argenxglobal.

argenx has built one of biotechnology’s most productive antibody engines. We’ll be putting Chai’s frontier molecular design platform into the hands of their scientists.

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Joshua Meier

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