Juan Pablo Tosar

@jptosar

RNA & molecular biology. Head of the Analytical Biochemistry lab at @FCienUdelar and the Functional Genomics lab at @IPmontevideo.

Montevideo, Uruguay tosarlab.com Joined August 2013

1.1K Following 2.5K Followers 3.9K Posts

Latest posts 5

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Juan Pablo Tosar @jptosar May 7, 2025

Now published at @CellGenomics! Substantial amounts of new data added from the preprint version (thank you Editor and reviewers!). But the thread below still works.

TL/DR: naked RNA can enter cells & cells respond. RNases in the blood prevent that.

cell.com/cell-genomics/…

Juan Pablo Tosar @jptosar Apr 24, 2024

📌Preprint alert!

Can naked extracellular RNA enter cells? Can it escape from endosomes into the cytosol? Can naked extracellular mRNAs be translated if not encapsulated in EVs or LNPs?

Why do we have so many RNases in the blood? 🤔
A thread 🧵🪡
biorxiv.org/content/10.110…
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Juan Pablo Tosar @jptosar Oct 1

Is the RNA in our blood just fragile debris, or a readable record of how the body responds to disease? 🧬🩸 In our new Opinion in @TrendsBiochem, we propose a framework for cfRNA fragmentomics.

Juan Pablo Tosar @jptosar Sep 30

Because this will be a 10/10 meeting, we are extending registration, fellowship applications and abstract submissions until October 10th (10/10).

We are close to be fully booked so hurry up!

Juan Pablo Tosar @jptosar Jul 9

Here we go: #MONT2027 - Montevideo School on Oligonucleotide & RNA Therapeutics.

Frontier science for researchers; a unique chance for regional trainees to learn from leaders in the field.

Supported by @OTSociety & @ICGEB.

Applications opening soon.

m-ont.org

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Juan Pablo Tosar @jptosar Aug 1

Happy #RNAday (AUG1)! 🧬

To celebrate, we are opening applications for #MONT2027 next Monday! Stay tuned for the application link, that I will share in the comments.

@OTSociety
@ICGEB
@RNASociety

Juan Pablo Tosar @jptosar Jul 9

Here we go: #MONT2027 - Montevideo School on Oligonucleotide & RNA Therapeutics.

Frontier science for researchers; a unique chance for regional trainees to learn from leaders in the field.

Supported by @OTSociety & @ICGEB.

Applications opening soon.

m-ont.org

View quoted post on X

Juan Pablo Tosar @jptosar Jul 9

Here we go: #MONT2027 - Montevideo School on Oligonucleotide & RNA Therapeutics.

Frontier science for researchers; a unique chance for regional trainees to learn from leaders in the field.

Supported by @OTSociety & @ICGEB.

Applications opening soon.

m-ont.org