@kchenken
Delighted to share our Cancer Cell paper published today, co-authored by Dr. Alexander Biederstädt @ABiederstadt_MD and Dr. Rafet Basar @rftbsr9 reporting the first genome-wide CRISPR screen in primary cord blood NK and CAR NK cells. We identify key genetic checkpoints including MED12, ARIH2 and CCNC and show that their deletion enhances CAR NK cell antitumor activity in multiple tumor models. Congratulations to Alex for leading this study, to Rafet for his major contributions, and to all of our collaborators and co-authors for making this work possible.View quoted post on X
cell.com/cancer-cell/fu…
@MDAndersonNews @kchenken #NK #CRISPR #immunotherapy #endcancer
New #JITC article: Histologic and immune characterization of cutaneous immune-related adverse events induced by immune checkpoint inhibitors bit.ly/4oD8LzK
@AnishaPatelMD @cara_haymaker @ANaingMD @MDAndersonNewsView quoted post on X
Please check out our paper published today in Nature that identifies CREM as a key checkpoint limiting CAR NK cell function.CRISPR knockout of CREM significantly enhanced anti-tumor activity, implicating a broader role in NK cell regulation. Huge congrats to @hindrafei and ourView quoted post on X
Now online in @CD_AACR: Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade - by Xianli Jiang, @kchenken, Maura Gillison, and colleagues doi.org/10.1158/2159-8… @MDAndersonNewsView quoted post on X
