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Ryan Kibler

@kribler

Protein whisperer and resident 3D printing artist @UWproteindesign
Seattle, WA Joined December 2009
148 Following 203 Followers 41 Posts

Latest posts 3

Ryan Kibler @kribler
One of the coolest things you'll see this decade
Adam Broerman @adam_broerman Sep 24, 2025
We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
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Ryan Kibler @kribler
Breaking a big problem into smaller pieces and solving them one by one is a good strategy for designing a protein (and navigating life in general). Check out the @biorxivpreprint where we apply this idea to designing pseudosymmetric hetero-oligomers!
biorxiv.org/content/10.110…
www.biorxiv.org Stepwise design of pseudosymmetric protein hetero-oligomers Pseudosymmetric hetero-oligomers with three or more unique subunits with overall structural (but not sequence) symmetry play key roles in biology, and systematic approaches for generating such...
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