Luca Laraia

@laraialab

Research lab working on chemical biology of sterol-mediated processes at the Technical University of Denmark (DTU).

Copenhagen, Denmark kemi.dtu.dk/laraia Joined November 2017

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Luca Laraia @laraialab Sep 7

NEW PREPRINT! Excited to share our first paper on steroidal bifunctional probes! We synthesized a library (14) of bifunctional (diazirine/alkyne) steroidal probes by systematically varying the position and connectivity of the key functional handles. (1/4) chemrxiv.org/doi/full/10.26…

chemrxiv.org Bifunctional, Steroidal Photoaffinity Probes Enable Targeting of Sterol Transport Proteins |... Intracellular cholesterol transport plays a key role in maintaining cholesterol homeostasis, which is essential for human health. To map the cholesterol interactome, bifunctional steroidal photoaff...

Luca Laraia @laraialab Jun 24

Check out our new paper in @JACS_Au on the early- and late-stage chemoenzymatic functionalization of steroid-inspired compounds! (1/5)
pubs.acs.org/doi/10.1021/ja…

pubs.acs.org Early- and Late-Stage Chemoenzymatic Functionalization of Steroid-Inspired Compounds Abstract. Selective C–H functionalization of small molecule leads is a powerful approach for efficient chemical space exploration and medicinal chemistry o

Luca Laraia @laraialab Feb 4

Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here @HoganBryceRoge1, @Laura_dta and @tomeveriss describe in detail our assay cascade to identify inhibitors of sterol transport proteins. (1/2) sciencedirect.com/science/chapte…

Luca Laraia @laraialab Dec 2, 2025

Happy to share our latest paper in @rsc_medchem as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/art…

Luca Laraia @laraialab Nov 27, 2025

Delighted to have collaborated with the @DirkTrauner lab on the development and characterisation of #photoswitchable #cholesterol derivatives, now out in @J_A_C_S! Led by Michael Zott, with excellent work from @Laura_dta from our group @ChemistryDtu pubs.acs.org/doi/full/10.10…

pubs.acs.org Development of Photoswitchable Cholesterol Derivatives through Side Chain Replacement Abstract. Cholesterol is ubiquitous in biology, shaping membrane properties and serving as a biosynthetic precursor for essential signaling molecules and h