Evan Macosko

@macosko

Genomics technologist, Psychiatrist, Associate Professor, Massachusetts General Hospital @broadinstitute. Founder, Curio Bioscience

macoskolab.com Joined May 2012

328 Following 2.9K Followers 81 Posts

Latest posts 5

Evan Macosko @macosko Dec 13, 2023

We now know the locations of cell types in a full mammalian brain.

Our work reveals the brainstem’s absolutely stunning cellular complexity. How and why does it arise?

Visit braincelldata.org to plot genes, localize types, and get markers.

nature.com/articles/s4158…

Evan Macosko @macosko Dec 13, 2023

Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods:

1) Cell segmentation (the biggest problem)
2) robustness and scalability (well-powered case-control studies now possible)
3) Multiomics (ATAC, RNA, etc)

Broad Institute @broadinstitute Dec 13, 2023

A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags

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Evan Macosko @macosko Sep 28, 2023

Utilizing rare human brain biopsies we address:
1) Which cell types likely make amyloid?
2) How do microglia respond to amyloid and how does this compare to states in mouse models?
3) What neuronal states precede cell death in AD?

Paper out today!
cell.com/cell/fulltext/…

www.cell.com Early Alzheimer’s disease pathology in human cortex involves transient cell states Generating single-nucleus atlas from cortical biopsies of living individuals at early stage of Alzheimer’s disease, cell states of neurons, microglia, and oligodendrocytes associated with AD pathol...

Evan Macosko @macosko Jun 6, 2023

How does brain tissue change when amyloid first appears in the brain? In rare surgical biopsies, we find a hyperactive neuronal state preceding loss, and evidence of oligodendrocytes, as well as neurons, producing amyloid.

biorxiv.org/content/10.110…

Evan Macosko @macosko Apr 4, 2023

All single cell assays can now be spatial. Slide tags is simple, reliable single cell with hi-res spatial positioning. A truly outstanding scientific team: @insitubiology, @andyrusss, @jacksonweir4, Naeem Nadaf.

biorxiv.org/content/10.110…

www.biorxiv.org Slide-tags: scalable, single-nucleus barcoding for multi-modal spatial genomics Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells, transforming our understanding of how complex...