Magness Lab

NEC can destroy a premature infant’s intestine from mucosa to muscle. No single cell type tells that story.

We profiled 53,735 nuclei across the full wall, then built the manuscript like a world atlas: broad patterns and detailed cell-type entries.

doi.org/10.64898/2026.…

What happens to human intestinal stem cells during hypoxia? Rivera & Bliton et al from the Magness Group build a microphysiological hypoxia system, assess ISC viability, HIF1a, transcriptomics during acute/chronic hypoxia and show hypoxia primes ISCs for interleukin responses.

Also... Check out the newly updated Magness Group Website! magnesslab.org

Meryem Ok et al in the Magness Group show C. diff receptor expression in single cells across the human gut, transcriptomic differences in primary colonocyte and Caco2 maturation, a 2D colonic cell system to evaluate TcdA/B, demonstration of uncoupled apical/basal toxicity. 👍

Tired of not being able to access your organoid’s lumen? In our new CMGH publication, we developed a high-throughput 2D human enterocyte culture model for studying lipid transport and found that anti-diabetic drug metformin enhances fatty acid export via b-oxidation.