Marcus Goncalves

New paper out in @cellpressblue ! We found that reintroducing refined starch after weight loss activates the innate immune system through the complement pathway, while sugar has the opposite effect. With @eze_dantas , @davidludwigmd , CaraEbbeling, @CantleyLab , and team. 🧵

Adding new T-REx data to my plot of muscle loss vs weight loss from GLP1RAs. Still no convincing evidence that they cause disproportionate muscle loss.

Resistance exercise on tirzepatide: 3 supervised sessions a week for 40 weeks bought back 1.1 kg of lean mass, about 23% of the loss. Lean mass still fell 3.6 kg. Real-world adherence will be far below 91% and no reimbursement for hosting these sessions. Effort versus payoff. nature.com/articles/s4159…

Congratulations to Faeth and @GOG investigators on PIK-201. Serabelisib + sapanisertib + paclitaxel in PAM-mutant endometrioid endometrial cancer, 98% post-IO: ORR 33%, mPFS 7.4 mo. Chemo alone in this setting: ORR ~15-17%, mPFS 3.8-3.9 mo. Roughly 2x on both. $FTH investors.faeththerapeutics.com/news-releases/…

Congrats to the Faeth team!