Max Sosa

@maxbsosa

JSPS Postdoctoral Fellow with Ikuro Abe | @MChangGroup + UC Berkeley alum | biosynthesis

Tokyo-to, Japan Joined October 2018

155 Following 129 Followers 196 Posts

Latest posts 5

Max Sosa @maxbsosa Sep 30, 2024

I'm finally on my way! After a long, relaxing summer, I'm finally headed to Tokyo as a @jsps_sns Postdoctoral Fellowship. I'll spend the next few years working with Prof. Abe and the many talented scientists @UTokyo_News Lab of Natural Products Chemistry.

Max Sosa @maxbsosa Jul 12, 2024

Interesting how unrelated Fe-S clusters with different cluster geometries both facilitate LA-catalyzed DA reaction in biosynthesis. Would be cool to see how various ferredoxins fare against panels of inter/intramolecular DA substrates nature.com/articles/s4146…

www.nature.com Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis Nature Communications - Native enzymes using Lewis acid catalysis in intramolecular [4+2] cycloaddition remain unreported. Herein, the authors report the ferredoxins catalyzed [4+2] cycloaddition...

Max Sosa @maxbsosa Jun 3, 2024

What an unexpected strategy for making enediyne scaffolds!

Shen Lab @lab_shen Jun 3, 2024

We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio
nature.com/articles/s4158…

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Max Sosa @maxbsosa Mar 28, 2024

We got the published version out! During review, we re-examined our stereochemical assignment of absolute configuration. Thanks to @biotools we were able to use vibrational circular dichroism to confidently assign the abs. config. of pazamide :)

MChangGroup @MChangGroup Mar 23, 2024

Check out the published version in @angew_chem!

onlinelibrary.wiley.com/doi/abs/10.100…
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Max Sosa @maxbsosa Dec 14, 2023

Excited to share this work! Inside, we look at how Nature biosynthesizes a new non-canonical amino acid, how that AA may interact with plants, and how we can utilize a new PLP-dependent enzyme to make cyclopropanes and cyclobutanes!

MChangGroup @MChangGroup Dec 14, 2023

Check out our lab’s latest preprint on the biosynthesis of amino acids that feature strained rings. @maxbsosa discovered that these gene clusters contain a PLP-dependent enzyme that forms the ring from a halogenated substrate. biorxiv.org/content/10.110…
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