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1/n A webinar from @CDC_Genomics on Mendelian randomization (MR) highlights some under-appreciated aspects of MR; this thread outlines these youtube.com/watch?v=pc3uQz…
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Is the story of shingles vaccine preventing dementia just too good to be true?
We have a commentary out on some really interesting findings by colleagues in UCL and Finland on some of the maths behind some of the high profile shingles -> dementia analyses. In brief +View quoted post on X
Paper: pubmed.ncbi.nlm.nih.gov/42456671/
Commentary: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
Great opportunity to join team @gushamilton
Funded GW4 PhD available to apply for with me and Bill Horsnell, looking at early life infection in ALSPAC and asthma with PhiP-Seq. Will be v cool data!View quoted post on X
gw4biomed.ac.uk/early-life-inf…
I enjoyed giving the annual "distinguished lecture" on triangulation of evidence at Cambridge Uni Medical school, particularly as I could remind them at the beginning that they had tried to throw me out when I was a clinical medical student there youtu.be/e2ttItEnwCU
www.youtube.com Distinguished Lecture: Evidence triangulation: moving from correlations to causes On 16 October 2025, George Davey Smith visited Cambridge to deliver... A long thread on a quasi experimental study modelled on the @Nature paper using Welsh data and suggesting live shingles vaccine protects against dementia. Sadly in 20 times the sample size using precisely the same quasi experimental design we showed no such apparent protection