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Payam A. Gammage

@mito_oncogene

Mitochondrial genetics, genome engineering, cancer metabolism. Lab supported by ARIA, ERC & NCI. EMBO Young Investigator.
Glasgow, Scotland shorturl.at/lowCL Joined February 2019
269 Following 1.9K Followers 620 Posts

Latest posts 5

Payam A. Gammage @mito_oncogene
Fantastic and important use of AI, data science and the clinical record. Bravo @ZiadBakouny & @EdReznik 👏
Ziad Bakouny, MD, MSc @ZiadBakouny Sep 18
Some patients treated with cancer systemic therapy develop only minor side effects, others develop life-changing toxicities.

We have no tools to predict who will fall into which bucket.

Excited to share our ~3 years of work to try to figure this out:
medrxiv.org/content/10.648…
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Payam A. Gammage @mito_oncogene
🚨 really pleased to post a new preprint from our lab, where we describe an ancient metabolic axis that controls mtDNA copy number and mitochondrial content; a mechanism we uncovered in human cells that stretches through evolution to control mtDNA in flies, yeast and even plants!
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Payam A. Gammage @mito_oncogene
Very intriguing! Inter-organellar buffering effects with specific types of dysfunction! Congratulations @CBJacksonLab and colleagues! 👍👍👍
JacksonLab @CBJacksonLab Dec 3, 2025
🚨 New from our lab (est. 2020) — now published in Nature Communications!
🧬We uncover a surprising link between the v-ATPaseand mitochondrial function:
Mild v-ATPase inhibition restores cell fitness under mitochondrial mistranslation stress
nature.com/articles/s4146…
(Thread ⬇️)
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