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Marc Lipsitch

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@mlipsitch

This place is getting more sinister, maybe on my way out. Director @CCDD_HSPH Tweets in personal capacity. Didn’t pay for blue check
Boston, MA hsph.harvard.edu/faculty/marc-l… Joined September 2009
1.6K Following 196K Followers 11K Posts

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Marc Lipsitch Verified account @mlipsitch
Excited to share a new preprint led by Indra Gonzalez Ojeda on a new tool to improve pangenome calling in bacteria, CLARC. biorxiv.org/content/10.110… . Passing output of Roary for S. pneumoniae populations through this tool reduces accessory genome > 30%, resolves other puzzles
www.biorxiv.org Linkage-based ortholog refinement in bacterial pangenomes with CLARC Bacterial genomes exhibit significant variation in gene content and sequence identity. Pangenome analyses explore this diversity by classifying genes into core and accessory clusters of orthologous...
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Marc Lipsitch Verified account @mlipsitch
Just out w @chrisbboyer academic.oup.com/aje/advance-ar… Emulating target trials of postexposure vaccines using observational data. Spurred by great collab with @nycHealthy on mpox vaccines, but applies to any postexposure intervention on an infection to reduce risk of bad outcomes.
academic.oup.com Emulating target trials of postexposure vaccines using observational data Abstract. Postexposure vaccination has the potential to prevent or modify the course of clinical disease among those exposed to a pathogen. However, due to