Sharad Kumar @molregulation · Apr 18, Apr 18, 2026, 7:41 PM A new perspective on Caspase-2 sciexplor.com/articles/EXO.2… sciexplor.com The caspase-2 paradox in liver polyploidy and cancer risk Caspase-2 is a key genome-surveillance protease that functions to kill or arrest cells with abnormal chromosome content, via PIDDosome-dependent and -independent mechanisms. However, this surveilla...
Sharad Kumar @molregulation · Apr 9, Apr 9, 2026, 10:17 AM Our recent review on the regulation of inflammation by ubiquitination is now out! nature.com/articles/s4141… www.nature.com HECT ubiquitin ligases as regulators of inflammatory signalling Cell Death & Differentiation - HECT ubiquitin ligases as regulators of inflammatory signalling
Sharad Kumar @molregulation · Apr 9, Apr 9, 2026, 9:31 AM Excited to share our latest article reviewing the role of HECT family of E3 ligases in inflammation. @AusCellDeathSoc
Sharad Kumar @molregulation · Apr 2, Apr 2, 2026, 11:38 PM An interesting new function of Ndfip2, now published in Cell Death & Disease:doi.org/10.1038/s41419… www.nature.com Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of... Cell Death & Disease - Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels
Sharad Kumar @molregulation · Apr 2, Apr 2, 2026, 11:31 PM Now out in the April 2 issue of Cell- an important resource for the cell biology community.The E3-ome gene-centric compendium reveals the human E3 ligase landscape: Cell cell.com/cell/fulltext/… www.cell.com The E3-ome gene-centric compendium reveals the human E3 ligase landscape The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented...