Following up on our AI-IDP preprint:
Accurate local structure is sufficient to reconstruct IDP ensembles that reproduce
• local structure
• pairwise contacts
• global dimensions
→ Global behavior emerges from local bias. A shift in how we think about disorder.
Accurate local structure is sufficient to reconstruct IDP ensembles that reproduce
• local structure
• pairwise contacts
• global dimensions
→ Global behavior emerges from local bias. A shift in how we think about disorder.
IDPs make up a large fraction of the human proteome, yet predicting their conformations has remained a major challenge. In this study we introduce AI-IDP, a framework that links amino-acid sequence to NMR-consistent ensembles biorxiv.org/content/10.648…View quoted post on X
