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Nima Alidoust

Verified account Tahoe

@nalidoust

CEO and Co-Founder, @tahoe_ai, Princeton PhD *15 زن، زندگی، آزادی
tahoelabs.ai Joined March 2015
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Nima Alidoust Verified account @nalidoust
We are making Tara available to the public. Tara is a plug-in we developed internally to connect reasoning models with our datasets and the tools we build on top of them. Going forward, Tara will be the channel through which @tahoe_ai releases some of our other frontier datasets and models. Stay tuned.

You can connect your agent to Tara with a single prompt. It currently includes our Tahoe-100M dataset and its derivatives. It is particularly good at making connections between Tahoe’s data and other public datasets and models.

Our team, from AI scientists to drug hunters, has been using Tara extensively for a wide range of tasks. It has become a foundational tool for building and conducting research on large-scale biological datasets. We have been constantly surprised by how frontier AI, coupled with Tara, can uncover non-obvious connections across vast sources of biological data and enable discoveries that were difficult to imagine before.

We are excited to see what other creative minds do with it.
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Nima Alidoust Verified account @nalidoust
What makes a biological reasoning task verifiable? Our team @tahoe_ai has spent the last few months on that question and landed on one conviction: for human-difficult tasks with verifiable rewards, the answer key has to come from ground-truth experimental data.

Along the way we built thousands of such environments, which we call TahoeMysts, and we use them to evaluate frontier models (among other things). Every so often a new model produces a big jump, and it is always exciting. Today is one of those days: @claudeai Mythos 5.2!

We will say more about this work in the future. In the meantime, take a look at our results today.
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Nima Alidoust Verified account @nalidoust
I hope that this is not true.

And if it is and if @realDonaldTrump indeed has hesitations, I hope that those hesitations will win out as this would bring about unspeakable catastrophe for the people of Iran, who are the true victims of their rulers.
Tucker Carlson Verified account @TuckerCarlson Nov 2
Under pressure from Israeli prime minister Benjamin Netanyahu, the Trump administration may be within days of launching a nuclear strike on Iran. The target would be Pickax Mountain in central Iran, where Israeli intelligence claims the Iranian government has restarted its nuclear enrichment program. No conventional weapon in the American arsenal can penetrate 300 feet of solid granite to destroy the tunnels where enrichment is supposedly taking place. The only military option is a nuclear strike. Netanyahu has been pushing hard for one. “Bibi calls Trump about it every day,” says an informed observer.

Netanyahu is cornered and desperate. After last week’s election results, he can’t form a government unless Trump intervenes directly in Israeli politics and brokers a deal with other parties that gives Netanyahu 61 seats in the Knesset. Otherwise, he is out as prime minister and on his way to ignominy, investigations and possibly jail. Netanyahu must stay close to Trump. He needs this war.

To that end, he’s applied maximum pressure to his closest allies in the administration, including Secretary of Defense Pete Hegseth and CENTCOM commander Brad Cooper. Both oppose a negotiated settlement to the war they’ve so grievously mismanaged; both are pushing to restart major combat operations. Secretary of State Marco Rubio and CIA director John Ratcliffe are also following Netanyahu’s lead, as are leaders of the Democratic Party. In a recent meeting on the subject, former president Barack Obama said he opposes the current Iran peace deal being drafted in Doha.

The rest of America’s longtime allies in the Middle East are terrified by the prospect of more war. On September 27th, Netanyahu flew secretly to Abu Dhabi to enlist the UAE in his lobbying effort for a final attack on Iran. The Emiratis refused. After eight months of conflict, Gulf economies are teetering. So are global energy and fertilizer markets. They won’t recover soon. Globally, there are a total of about 850 supertankers used to transport oil from producers to the rest of the world. In October alone, 11 of them were badly damaged in Hormuz. At this pace, a global depression is imminent. A nuclear strike would radically accelerate the destruction. Fallout from a ground explosion at Pickax Mountain would contaminate the Persian Gulf, poisoning the water supply for 100 million people.

And those are just some of the immediate consequences for the region. The rest of the world is every bit as exposed. No country other than the United States has ever used a nuclear weapon in war. Some would like to. An American nuclear attack on Iran would set a new precedent. The Russians have already told at least two other governments that an American nuclear strike on Iran would free them to use nuclear weapons against Ukraine. Pakistan and India would be tempted to do the same against each other, as would North Korea against Seoul. After the first nuclear strike, World War Three is inevitable. That war would be short and final.

We’ve been sleepwalking toward this moment for months. Since February, the administration has quietly rewritten America’s nuclear doctrine to make first use of so-called “battlefield nukes” easier and therefore more likely. No one in Washington in either party seems bothered by this. Now we’re on the brink of it.

Close observers say Trump is likely to decide by next weekend whether or not to use nuclear weapons. That would be November 7, six days from now. To his credit, he’s hesitating. At the moment, Trump is listening to his vice president, JD Vance, and to his envoy and friend Steve Witkoff, both of whom argue a deal with Iran can be made.

They’re right, though it won’t be simple. The Iranians are famously frustrating to negotiate with under any circumstances, and elements of that government have become more radical since Ayatollah Ali Khamenei and his family were killed in February. After decades of isolation, even relatively moderate Iranian leaders seem confused by how decisions are made in the West. (There is a widespread belief in Tehran, for example, that the United States government controls Israel.) But overall, people who have spoken to decision-makers in Iran say there is consensus there that more war is bad for everyone and a deal is worth making.

One group that hasn’t been consulted so far is the global population — the hundreds of millions of people who will be killed along with their children if Trump is pushed by Netanyahu into launching a nuclear strike next week. Now would be the time for them to speak up.
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Nima Alidoust Verified account @nalidoust
As promised, we are sharing another dataset through our Tara plug-in: Emerald Bay.

Emerald Bay measures how different cancer models respond to combination of drugs in 5 days (vs. 1 day, which was the case for Tahoe-100M). 5-day time course is designed to capture cell death in response to the treatment.

@tahoe_ai had previously open-sourced this dataset as part of our Rhaister release. And now you or your agents can access it through The Tara plug-in. We will release more and more datasets in the next few months.

Tara access: tahoelabs.ai/tara
More about the dataset in the Rhaister paper: tinyurl.com/rhaister
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Nima Alidoust Verified account @nalidoust
It was a while ago that @BenjamineYLiu shared this concept with me over coffee and I thought it made so much sense.

I think this is not just a new fund. It is a new blueprint - for building investment engines whose alpha and edge is not just the consumption and synthesis of facts; but a compounding core, a technology, and a system beyond human judgement.

Cheering for you!
Ben Liu Verified account @BenjamineYLiu Oct 28
Today we’re announcing the $600M Formation Bio Drug Development Accelerator Fund.

@lintaho and I started @FormationBio because we believed the biggest bottleneck in bringing new medicines to patients wasn’t drug discovery, but drug development.

As AI dramatically accelerates discovery, that bottleneck is only becoming more acute. Without the capital and capacity to advance promising drugs through clinical trials, much of that progress won’t translate into medicines for patients.

Our new Fund brings together dedicated capital, drug development expertise, and AI-powered development capabilities to acquire promising drugs and advance them through the clinic.
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