Oxford Nanopore

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@nanopore

We empower people to explore and answer biological questions with our transformative sensing technology.

Oxford Joined May 2009

8.7K Following 66K Followers 20K Posts

Latest posts 5

Oxford Nanopore @nanopore 2d

Bisulfite can’t tell 5mC from 5hmC. For years, they’ve been read as one signal.
Oxford Nanopore reads native DNA and calls both modifications from the same molecule, alongside the sequence.

Gold-standard methylation, with 5mC & 5hmC kept apart.

nanoporetech.com/applications/i…
#WeRunIt

A poster with a bright yellow background features the hashtag "#WeRunIt" in the top right corner. A large quote reads, "Finally, someone can tell us apart." Below it is "5hmC," which stands for 5-hydroxymethylcytosine, next to an image of a scientific instrument displaying three DNA sample slots. At the bottom, text reads, "Native methylation, read directly from the molecule." The image is credited to Oxford Nanopore Technologies plc.

Oxford Nanopore @nanopore 3d

Two @UMich studies demonstrate the potential of #AdaptiveSampling. Published in @ACCR Journals and @NEJM, the studies resolved 32 of 46 tumours that standard sequencing couldn't and traced a child's tumour after gene therapy to a vector inserted into GLI1

michiganmedicine.org/health-lab/com…

Oxford Nanopore @nanopore 4d

Today, the NHS Respiratory Metagenomics Network have published a paper in Nature highlighting practical principles that could support the wider rollout of rapid #metagenomics nanopore sequencing in the future.

nature.com/articles/s4385…

Oxford Nanopore products are RUO.

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Oxford Nanopore @nanopore 5d

#AdaptiveSampling gives you depth on your targets and a low-pass view of the whole genome, in a single run. Methylation, SVs, SNVs and CNVs, all from native reads. See the targets you need and the biology you didn't expect.

nanoporetech.com/applications/t…

#WeRunIt

Oxford Nanopore @nanopore 6d

Join Kimberley Billingsley as she discusses how a large-scale Oxford Nanopore WGS resource was built across multiple postmortem brain cohorts to reveal structural variants and repeat expansions linked to Alzheimer's disease and related dementias.

bit.ly/3UkAb30