NefzgerLab 🦋 @nefzgerlab.bsky.social

Our new @Cell_Metabolism study proposes a mechanistic connection between molecular remodelling in development & aging. We uncovered a common transcription factor pattern linked to chromatin remodelling in organismal maturation & aging.
Link tinyurl.com/d39ru3s8
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🙏 to Manuel Serrano for writing a preview 👉 doi.org/10.1016/j.cmet… for our study NOW IN PRINT @Cell_Metabolism. We introduce the "Stimulus-Induced Programming Hijacks Ontogeny" (SIPHON) model for chromatin & transcriptome remodeling in organismal maturation & aging

We provide compelling data that “cell identity loss” in aging represents the hijacking of a developmental mechanism via epigenetic de-repression of AP-1 rich regulatory elements through stress/stimulus processes. The resulting predictable transcription factor network changes may drive many aging phenotypes.

Link to our study 👉 doi.org/10.1016/j.cmet…

It was an absolute pleasure to work with @Cell_Metabolism & @AmberMuellerPhD

The project spanned 15 labs and was led by talented co-first authors @rjPatrick19 & @MarinaNaval, with crucial contributions from @nikkideshpande, Yifei Huang @Jason836452, Jingyu Zhang @IAMorlandozhang, Xiaoli Chen, Ying Yang @haokandeyy, @Mohammad_E1990, Kanupriya Tiwari,  Minh Tran, @AMohamed85, Binxu Wang, Di Xia, Jun Ma, Jacqueline Bayliss, Kahlia Wong, Michael Hun, @Sallyxsun, Benjamin Cao, Denny Cottle, Tara Catterall, Hila Barzilai-Tutsch, @robinleetroskie, @ZhianAnthony, Andrea F. Wise, Ye Mon Soe, Snehlata Kumari @Sne_K, @TheSweetGroup, Helen Thomas, Ian Smyth, Anne Fletcher @ImmunologyMelb, Konstantin Knoblich, @MattWattUnimelb, Majid Alhomrani,  @WalaaAlsanie, @DrQuinn4realz, @Tobias_Merson, Ann Chidgey, @SharonRicardo1, @YUmmunology, @JardeThierry, @SethCheetham, Christophe Marcelle, Susan Nilsson, @Quan_Nguyen_UQ & @MelanieDWhite

Thanks! We provide compelling data that “cell identity loss” in aging represents the hijacking of a developmental mechanism via epigenetic de-repression of AP-1 rich regulatory elements. The resulting predictable transcription factor network changes may drive many aging phenotypes

We show AP-1-linked chromatin opening underpins transcription factor network remodelling during maturation across cell types (e.g. to slow growth/early-life processes). Ongoing chromatin opening (e.g. via inflammation/systemic factors) further dampens early-life circuitry as antagonistic pleiotropy

Paper link: doi.org/10.1016/j.cmet…

Excited that Channel 7 & 9 covered our @Cell_Metabolism study along with 62 news outlets. It suggests AP-1-linked chromatin opening drives organismal maturation across cell types by disrupting the activity of 'early-life' gene regulatory elements—a mechanism hijacked in aging via ongoing chromatin opening.

Thanks @hema_news for ranking this collaborative study with the lab of the amazing Susie Nilsson as your top runner up tweet for 2021. @CSIRO @ARMI_Labs @IMBatUQ