Oncogene Journal

@oncogenejournal

Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research.

London nature.com/onc Joined July 2018

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Oncogene Journal @oncogenejournal 11h

ADORA1-driven metabolic reprogramming promotes therapy-induced senescence and chemoresistance, while senolytic or ADORA1-targeted interventions re-sensitise tumours to treatment.
nature.com/articles/s4138…

www.nature.com Therapy-induced tumour senescence drives oxaliplatin resistance via ADORA1–dependent palmitic acid... Oncogene - Early resistance to oxaliplatin-based neoadjuvant chemotherapy (NACT) remains a major obstacle to improving outcomes for patients with locally advanced colorectal cancer (CRC). We found...

Oncogene Journal @oncogenejournal 4d

Combining MRI-guided sampling with molecular profiling, the study reveals how dysregulated PKA signaling distinguishes clinically significant prostate cancer. Read more >>>>
nature.com/articles/s4138…

www.nature.com Disassembly of PKA holoenzyme organization marks prostate cancer progression Oncogene - Disassembly of PKA holoenzyme organization marks prostate cancer progression

Oncogene Journal @oncogenejournal 5d

New study shows early transcriptional and #immune signatures distinguished responsive from resistant TNBC tumours days before measurable changes in tumour volume
nature.com/articles/s4138…

www.nature.com Early temporal transcriptional and cytokine responses distinguish chemotherapy sensitivity in... Oncogene - Early temporal transcriptional and cytokine responses distinguish chemotherapy sensitivity in patient-derived xenograft models of triple-negative breast cancer

Oncogene Journal @oncogenejournal Nov 3

SIRT3-SLC25A13 signalling axis controls NAD⁺/NADH homeostasis and mitochondrial dysfunction-associated senescence (MIDAS) nature.com/articles/s4138…

www.nature.com SIRT3 deficiency triggers mitochondrial dysfunction-associated senescence to suppress colorectal... Oncogene - SIRT3 deficiency triggers mitochondrial dysfunction-associated senescence to suppress colorectal cancer progression via SLC25A13 acetylation

Oncogene Journal @oncogenejournal Oct 28

New research reveals how #LiverCancer cells evade immune defenses by altering fatty acid uptake. Loss of FATP5 causes fat accumulation in neighboring blood vessel cells, triggering immune exhaustion and tumor progression.

nature.com/articles/s4138…

www.nature.com FATP5 loss in hepatocellular carcinoma cells orchestrates tumor-promoting microenvironment by... Oncogene - Liver cancer is a deadly disease known for shutting down the body’s immune defense and altering how tumor cells use nutrients like fatty acids. In this study, we investigated how...