PeptAI

Next experiments confirmed for two programs: KISS1R, our fertility program, and OX2R, aimed at ADHD and sleep.

Our agents designed two lead peptides for each one, four in total, and so far they only exist as predictions on a computer.

The four peptides are now heading to a real lab for the first time.

The first step is synthesis, physically building the molecules. Because they contain non-natural amino acids (non-canonical amino acids), this needs specialized chemistry and takes about three weeks.

After synthesis, the peptides are routed for a functional cell assay.

Mammalian cell lines carrying the target receptor (KISS1R or OX2R) are grown in the lab, and each peptide is assayed to measure whether it switches the receptor on and how strongly. We also assess selectivity, to check whether off-target receptors could create problems down the line.

This is the first test of these designs, showing whether we have therapeutic candidates or need a subsequent round of optimization.

Take a look at what we’re learning with PeptAI in the @AnthropicAI x @adaptyvbio protein design competition.

We’ll keep sharing our computational designs and the methods behind them as the competition continues.

Read our learnings so far below and stay tuned for more.

Have a peptide or protein design project in mind?

We’re looking to partner with researchers who bring deep biological expertise to take projects from computational design to wet lab validation.

Tell us about your project at the link below ↓

The new PeptAI website is live 🧬

What's New:

• Pipeline overview: We’ve moved from a candidate view to a pipeline overview, making it easier to follow each project and see where everything stands.

• Start a project with us: Researchers and companies can now submit a research question or project idea through our contact form. Tell us what you’re working on and how we could help, and we’ll work with you to build a program around it.

Take a look ↓