The Pike Lab

@pike_lab

The Pike Laboratory led by Luke Pike @MSKCancerCenter @MSK_RadOnc seeks to improve care for patients afflicted by brain metastasis.

New York mskcc.org/research-areas… Joined July 2022

213 Following 250 Followers 62 Posts

Latest posts 5

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The Pike Lab @pike_lab Jul 25, 2024

@JCO_ASCO: TURBO-NSCLC (ascopubs.org/doi/10.1200/JC…) was a multi-institutional cohort study of 317 treatment-naive EGFR or ALK NSCLC pts with Brain Mets who received TKI w/wo up-front SRS. SRS was associated with superior CNS control.
@MSK_RadOnc
@MSKCancerCenter

ascopubs.org Tyrosine Kinase Inhibitors With and Without Up-Front Stereotactic Radiosurgery for Brain Metastases... PURPOSENewer-generation tyrosine kinase inhibitors (TKIs) for non–small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrang...

The Pike Lab @pike_lab Oct 10

Fantastic work led by @dtbergman analyzing 3,893 patients treated with Linac SRS for brain mets. OS plateaus from 5-20 lesions & salvage WBRT is rare. Data support an SRS-first strategy over fixed lesion limits! doi.org/10.1093/noajnl… @MSKCancerCenter @MSK_RadOnc

academic.oup.com Linac-based stereotactic radiosurgery for brain metastases: Survival and salvage treatment in a... AbstractBackground. Real-world outcomes after stereotactic radiosurgery (SRS) for brain metastases across the full burden spectrum are limited. We tested w

The Pike Lab @pike_lab Oct 10

Proud of work co-led by Emily Miao & Emily Wo uniting 11 centers for the largest cohort of tx-naive EGFR+ NSCLC brain mets. Genomic subtype drives CNS outcomes: L858R & atypical mutations benefit most from upfront SRS. sciencedirect.com/science/articl… @MSKCancerCenter @MSK_RadOnc

The Pike Lab @pike_lab Sep 17

The Pike Lab at @MSK_RadOnc has 13 abstracts at the upcoming @ASTRO_org 2026 AGM. Come check out how we are advancing the management of brain metastases.

The Pike Lab @pike_lab Sep 10, 2025

Brain metastasis is an uncommon but devastating event for pts with colorectal cancer. In work led by Drs. Gui and Walch @hswalch, we identify genomic features, present at initial diagnosis, that may help identify pts likely to develop BM. @MSKCancerCenter academic.oup.com/neuro-oncology…

academic.oup.com Genomics correlates of brain metastasis and progression in colorectal cancer AbstractBackground. Brain metastasis (BM) in colorectal cancer (CRC) is a rare event that undermines longevity and neurocognitive function. However, the mo