plasmidsaurus

Santiago Ramón y Cajal drew neurons. At booth 305, we’ll ask you to draw a dinosaur.

Come visit the Plasmidsaurus team at SfN in Washington, DC, November 15–18!

Stop by to:
- Hear what’s new with Plasmidsaurus RNA-Seq and our other sequencing services
- Add your art to our draw-a-dinosaur tradition
- Grab our SfN exclusive dino merch

📌 Catch our poster (LBP052) on Tuesday, November 17, 1–5 p.m.

Nicole Rapicavoli, PhD, Product Manager of RNA-Seq, is presenting “Charting the Transcriptional Life of the Mouse Hippocampus.”

🗣️ Presenting your own poster with data from Plasmidsaurus sequencing? We’d love to hear what you’re researching! Drop your poster number and session in the comments, and we’ll make sure to stop by.

See you soon in DC!

Every published paper that used Plasmidsaurus started with a team doing the hard science. We’re just glad our sequencing earned a line in their methods. 🦖

Now you can search those papers in one place: the Plasmidsaurus Citation Database, powered by Bioz.

Use it to:
• See how other labs used a service in experiments like yours
• Check what’s worked before you commit samples to a new approach
• Discover new papers in your field

Spot your own paper in there? Tell us below so we can celebrate it. 🎉

Browse the Database: plasmidsaurus.com/citation-datab…

Nucleosomes are usually seen as barriers transcription factors have to get past. Wei et al. (2026) show that barrier also helps: it keeps GCN4 from lingering at the wrong sites.

The team built minichromosomes, which are small, purified loops of DNA wrapped in real nucleosomes, and tracked single molecules of the yeast transcription factor GCN4 as it searched for its target gene.

Two independent mechanisms sharpen the search:
• Nucleosomes limit how long GCN4 lingers at off-target sites.
• GCN4’s intrinsically disordered region speeds up both binding and release, making the search faster and more selective.

Under the hood, the team verified their minichromosome constructs with Plasmidsaurus Whole Plasmid Sequencing, then mapped nucleosome positions from MNase-digested DNA with Plasmidsaurus Premium PCR Sequencing.

Molecular events on native, nucleosome-wrapped DNA have been hard to watch directly. This platform changes that, and it can be adapted to other chromatin-based processes like DNA replication and repair.

📄 nature.com/articles/s4159…

Plasmid errors are more common than you might think.

According to Addgene’s Senior QC Manager, about 30% of plasmids they receive have sequence discrepancies that need depositor feedback. And those errors can quietly lead to failed cloning, irreproducible results, and wasted bench time.

Be prepared to catch and prevent them by watching the Addgene × Plasmidsaurus webinar, now available on demand!

The webinar breaks down:
🧬 What Sanger, short-read NGS, and long-read sequencing each reveal about your plasmid
📊 How to read your sequencing results, including consensus Q-scores
🚩 Warning signs that a construct has a problem

Whether you're checking routine clones or validating a critical construct, walk away with a practical framework for choosing the right method and trusting your results.

Watch now: plasmidsaurus.com/webinar/webina…

The SF office is ready for Halloween. Enjoy the weekend, and may no contaminated preps haunt you 🎃