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Konrad Platzer

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@platzer_k

Genomics • 👨‍💻 • rare diseases • gene discovery • trying to be a clear thinker • optimist
Joined October 2019
568 Following 1.4K Followers 3K Posts

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Konrad Platzer Verified account @platzer_k
I thought about when & why I did change my outlook on things. What's going in my life, where am I going, how do I lead the team at work, the future in general, politics, simply everything. My old views on things were, plainly speaking, just not grounded enough in reality & logical thinking.

It is after reading @DavidDeutschOxf, that, step by step, I started to see the world with different eyes. I would not have read this book w/o recurring recommendations by the great @naval, who I quickly came across on Twitter after joining in 2019.

This is the most important book I have read in my life. The concepts I learned are a great north star. I am rereading the book right now. There is a ton of content on the it to better understand the core concepts here on X & YT by @ToKTeacher @arjunkhemani @astupple & many others.

Read it & see for yourself… 👌 👇
Konrad Platzer Verified account @platzer_k May 13, 2022
Finished reading “The Beginning of Infinity” by @DavidDeutschOxf. Completely blown away by it. Really changed my thinking + outlook on the future. Highly recommend it as your next book to read… 📚

Thanks to @naval & @ToKTeacher for spreading the word... 👌
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Konrad Platzer Verified account @platzer_k
I find this incredibly inspiring.
Eric Weinstein Verified account @ericweinstein Sep 26
Okay. I’ll take the bait.

I went to work for Peter in 2013 with opposite politics.

He sat me down right at the beginning.

PETER: “I don’t want the (Thiel) Foundation to do good that the market can do. That is the job of the market. Likewise, I don’t want to do the good work that is seen as good. That work can be done by people richer, weaker and more needy of approval than we are. I want us to do only the work that is *deeply* good but somehow confused for being evil, because that is the work of the courageous and the strong. We strive to be both and that is where a small foundation can make the greatest positive difference. Go look for such good and let’s do that. But remember. Good has TWO different antonyms. What is “bad work”? It could be seen as shoddy work. Or it could be seen as evil work. And we can’t do shoddy work. Why? Because evil that isn’t competent never gets to be evil. It’s just pathetic. So we have to be exceptionally competent at the good work which we do to make sure it is always confused for evil.”

I thought it totally logical. So that’s the argument. And that’s classic Peter.

This is an old idea of his. And now you know.
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Konrad Platzer Verified account @platzer_k
I grew up the most and also stopped searching by having kids.

Kids force you to take on responsibility you can’t or won’t take on without them.
Aaron Stupple Verified account @astupple Oct 25
Yes, the standard advice, to my ear, was to find yourself. Then everything else will fall into place.

I was constantly searching (and I spent a LOT of time with spiritual/mindfulness dreck.)

Having a bunch of kids has erased the searching. It’s abundantly obvious that I got a lot of important stuff done every day.

“Find yourself” is nonsensical on its face - how could you ever know that you’ve succeeded? The standard answer is you just know, as if we’d accept such a tautology as a legitimate way to think about anything important.
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Konrad Platzer Verified account @platzer_k
The recurrence risk for offspring of #NF1 patients could be as high as 61% and not 50% as in a standard autosomal dominant inheritance.

This transmission ratio distortion could be due to #NF1 null cells arising in the early primordial germ cells. Such a copy number neutral LOH event is a known mechanisms in NF1-associated tumors.

Very interesting arcticle in @GIMJournal. It could have direct implications for genetic counselling of neurofibromatosis families. More work is needed to follow up on this exploratory work. 👌👇
Not so Mendelian: NF1 variants were transmitted to offspring at higher-than-expected rates, suggesting transmission ratio distortion. bit.ly/3VFuyN2
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