Pluchino lab - Regenerative Neuroimmunology

@Pluchinolab

Developing experimental molecular medicines for chronic inflammatory diseases of the brain. 🇬🇧🇺🇸🇮🇹🇫🇷🇿🇦🇭🇰🇺🇦

🦋 Bluesky @pluchinolab.bsky.social

Cambridge, UK pluchinolab.org Joined September 2011

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Pluchino lab - Regenerative Neuroimmunology @Pluchinolab Oct 28

Excited to visit the @NeuroAlc in Alicante this Friday!

Can’t wait to share our latest data and get challenged with tough questions 🧠

Thanks @AlerieDe for the extremekly kind invitation.

#Neuroscience #regenerativeneuroimmunology

Instituto de Neurociencias UMH-CSIC @NeuroAlc Oct 28

We’re pleased to welcome Dr Stefano Pluchino @Pluchinolab, from @CentreMyelin @Cambridge_Uni, next Friday #SeminarsIN🙌
He is an expert in regenerative neuroimmunology, pioneering the development of stem cell and exosome-based therapies for neurological conditions. Don’t miss it!

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Pluchino lab - Regenerative Neuroimmunology @Pluchinolab 1d

Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis

cell.com/neuron/fulltex…

www.cell.com Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathog... Microglia-mediated neuroinflammation drives Alzheimer’s disease progression. In this article, Liu et al. show that the histone acetyltransferase KAT7 promotes mitochondrial DNA-dependent inflammation...

Pluchino lab - Regenerative Neuroimmunology @Pluchinolab 1d

The blood-brain barrier imports diverse neuroprotective proteins through pathways impaired early in Alzheimer’s disease models

cell.com/cell/fulltext/…

www.cell.com The blood-brain barrier imports diverse neuroprotective proteins through pathways impaired early in... Bioorthogonal proteomics reveals that the blood-brain barrier (BBB) imports diverse plasma proteins to specific brain cell types through receptor-mediated transport, a process dysregulated early in...

Pluchino lab - Regenerative Neuroimmunology @Pluchinolab 1d

Mitochondria-derived extracellular vesicles mediate Alzheimer’s disease pathology through transmitting microglial Ggt1

nature.com/articles/s4358…

www.nature.com Mitochondria-derived extracellular vesicles mediate Alzheimer’s disease pathology through transmi... Nature Aging - Li, Xia, Sun, Jia et al. identify a pathological role for mitovesicles in Alzheimer’s disease using patient brain samples and mouse models. Within mitovesicles, the authors...

Pluchino lab - Regenerative Neuroimmunology @Pluchinolab 3d

An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathology

cell.com/neuron/fulltex…

www.cell.com An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathology Early synapse loss tracks cognitive decline in Alzheimer’s disease. Sokolova, Puletti, et al. identify a regional perisynaptic astrocyte state in early amyloid pathology and show that astrocyte-der...