Rune Busk Damgaard

More evidence that LUBAC has functions beyond immune signalling. Our recent study shows that LUBAC and OTULIN regulate metabolic signalling: specifically they govern AMPK signalling to control metabolic adaption, autophagy, and cell death during energetic stress. This suggests that the metabolic symptoms observed in patients with LUBAC deficiency and ORAS, including glycogen storage disease, lipodystrophy, and liver disease, may be caused directly my metabolic dysregulation rather than being secondary to the systemic inflammation.

nature.com/articles/s4141…

It’s brutal - and, unfortunately, it’s perfectly normal. Most fundings bodies I know of give zero feedback and no reason for rejection.

🚨New preprint!🚨
Lack of specific affinity reagents hinders studies of signalling mechanisms. We show that sdAbs provide a robust scaffold for making linkage-specific ubiquitin binders, exemplified by 2A6, a versatile reagent for M1-linked ubiquitin.
biorxiv.org/content/10.648…

Hej @omDSB. Hvorfor kan man ikke købe returbilletter ud jeres nye “købsflow”? Hvorfor skal jeg købe to individuelle billetter og betale af to omgange? Jeg kan heller ikke vælge sæde? Men blot at jeg gerne vil have et…?Det er en seriøs downgrade af jeres billetbutik og service.