rico meinl

This account is verified. Learn more

@ricomnl

head of applied ai @retrobio_

bay area ricomnl.com Joined June 2018

465 Following 1.4K Followers 902 Posts

Latest posts 5

Pinned post

rico meinl @ricomnl Aug 22, 2025

super excited to announce our collaboration to the world! here’s the backstory: we started with a shared goal of using AI to generate novel discoveries that would be non-trivial for human scientists to make

Boris Power Verified account @BorisMPower Aug 22, 2025

At @OpenAI, we believe that AI can accelerate science and drug discovery. An exciting example is our work with @RetroBiosciences, where a custom model designed improved variants of the Nobel-prize winning Yamanaka proteins. Today we published a closer look at the breakthrough. ⬇️

View quoted post on X

rico meinl @ricomnl 16h

is this an implicit bear case on obicetrapib or am i misunderstanding the CETPi reference?

Dave A Ricks Verified account @DaveARicks 2d

Dissent is obviously key to the scientific process, I often worry about herd mentality in decision processes we have, but I suspect its much worse in academic medicine because reputation and hierarchy are the currency of the realm. That said this industry is really hard because differentiating between good ideas that just need more work (better drug, better experiment ala Amyloid Beta ) and bad ideas that should be dropped (dead end biologic target that is drugged well enough ala CETPi) is non obvious much of the time, until it isn’t. Too often after a ton of money and time invested in human CTs. So just listening to the dissenters isn’t good enough and neither is over simplified pattern recognition across biology - designing POCs that really test the idea much better.
View quoted post on X

rico meinl @ricomnl 5d

after all… why not? why shouldn't I watch artificial life emerge to figure out the right way to model biology?

Fraser Price Verified account @fraserpricee Nov 4

for some wild unknown reason, it seems im the only bloke scaling evolutionary simulation

(this emerges from pure random particle mutation/natural selection; like 👁️????👁️)

View quoted post on X

rico meinl @ricomnl Oct 30

mfw
>biology is just a data problem
>collect enough omics, simulate the whole cell
>read about humanin
>peptide encoded inside the mitochondrial 16S rRNA gene
>the same sequence is also a structural part of the ribosome
>24 aa if the cytosol translates it, 21 aa if the mitochondria do
>because mitochondria run a different genetic code
>and start translation with N-formylmethionine instead of plain methionine
>nobody's fully sure which one actually makes it
>also 13 nuclear copies that might make their own versions
>gets secreted into the blood
>hits cell-surface receptors
>one of them is literally a mitochondria detector
>also gets taken back up
>binds Bax inside the cell to block apoptosis
>discovered by screening surviving brain tissue from an alzheimer's patient
>open my cell model schema
>compartment: yes
>molecule_type: rRNA, peptide, hormone
>length: depends who's asking

rico meinl @ricomnl Oct 29

highly recommend. every time you walk away and it locks it goes ROOOAARRR. people in public parking were not amused

Nic Cruz Patane Verified account @niccruzpatane Oct 29

Tesla’s new Trick or Treat Mode is awesome. Make sure to enable it during Halloween this weekend.

(BTW, Tesla’s video production is 🔥)

View quoted post on X