David W

@rn_flex

Primary care NP, lover of glucagon agonism, incretin nerd, photographer, mountain lover, coonhound rescuer

Primary care land Joined October 2021

243 Following 1.2K Followers 4.3K Posts

Latest posts 5

The Lp(a) trial was very flawed. They over treated their own population by lowering the LDL so much and then *shocked Pikachu* face found a null result.

But look in the appendix and those with LDL>100 had a small signal.

Plus 20% DC rate! And only 73% reduction in Lp(a)

Eric Topol Verified account @EricTopol 18h

Today #AHA26 and @NEJM the 2 big trials of secondary prevention of heart disease with an IL-6 antibody and Lp(a) antisense oligonucleotide. No beneficial effect, overall and across all subgroups
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…

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David W @rn_flex Oct 20

Cuz me and Jen are nerds. Couple notes here. The length of trial indicates they're planning for 30% weight loss as the average which is nuts. RIP Bariatric surgery.

Also change in GFR. Elora ⬆️ GFR in phase 2 data

For DM2 composite >15% WL AND A1c <6.5% is ambitious AF

Jen Can NuSH Verified account @JCanNuSH Oct 20

🚨 EloraTZP AMPLIFY-1 and -2 Phase 3 trials have posted to clinical trials. 100 weeks! Wow! 😲

▪️AMPLIFY-1: Overweight/Obesity without T2D, 2100 patients and 8 ARMS!!! (5 Elora TZP, 1 Elora, 1 Tirz, and 1 placebo)

▪️AMPLIFY-2: Overweight/Obesity with T2D, 1000 patients and 2 arms (no placebo!). EloraTZP and Tirzepatide alone

Estimated end dates: End of 2029

AMPLIFY-1
clinicaltrials.gov/study/NCT07881…

AMPLIFY-2

clinicaltrials.gov/study/NCT07881…

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David W @rn_flex Oct 18

Big couple weeks for retatrutide and tirzepatide coming up. We get Reta + Tirz data this week for CKD. The sleep apnea data for Reta is on Friday. And then in early November we get the Reta + knee arthritis data! Then mid November cardiometabolic risk data for Reta.

David W @rn_flex Oct 9

First blush thought. Reta but more diarrhea, nausea/vomiting signal looks weird, increased lipase 15-20% is 🧐🧐 worth watching. Heart rate increases up to 10BPM, 6MG arm confounded ~25% of patients never took 6mg dose. Probably viable molecule but it'll be 3 years too late.

Michael Weintraub, MD @MWeintraubMD Oct 9

Cell metabolism publication: cell.com/cell-metabolis…
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David W @rn_flex Oct 7

Can an oral small molecule provide renal and cardiovascular benefits just like the injectable GLP1 meds? The answer is probably so! New blog post today about Achieve 4 the CV trial that was presented at EASD.

the-incretins.beehiiv.com/p/clearing-the…

the-incretins.beehiiv.com Clearing the CVOT hurdle O