My colleagues in genomics and statistics just published the method RETROFIT for reference-free deconvolution of spatial transcriptomics. The editors at Nature Communications just highlighted it as one of the best papers! nature.com/collections/cf…
www.nature.com Computational and Theoretical Biology As we navigate the era of big data in biological research, advanced computational techniques, such as mathematical models and machine learning algorithms, are ... ![Differential expression of globin genes by changes in interactions with the LCR. In these conceptual illustrations, interaction with a transcriptionally active zone [i.e., a hub, factory, or biomolecular condensate (yellow-orange ovals)] anchored on the LCR leads to the expression of a globin gene. Shifts in the genes interacting with the LCR active zone in erythroid cells at progressive stages of development result in differential expression. Areas with brown circles indicate repression. The different interactions are shown as occurring within the subTAD containing the LCR and globin genes. Similar shifts in patterns of interaction of genes with the LCR are indicated for both the (a) HBB and (b) Hba gene clusters. No information is currently available on LCR–gene interactions for the HBB locus in embryonic primitive erythroblasts, indicated by the dashed outline around the illustration. Abbreviations: HS, hypersensitive site; LCR, locus control region; TAD, topologically assoc. domain](/api/media?url=https%3A%2F%2Fpbs.twimg.com%2Fmedia%2FGy0PeDzXIAAcT1T.png)