The human-specific gene FRMPD2B couples postnatal experience to the expansion of cortical connectivity
biorxiv.org/content/10.648…
biorxiv.org/content/10.648…
Ruslan Rust
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Asst Professor @USC with interest in the brain, BBB, stem cells, AI + what can go wrong after stroke & AD. Alum @ETH_en. Fixing science @ResearchHub
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Interesting, will try out something similar to run a research lab 👇
I've changed how I work over the last few weeks.View quoted post on X
I now have one lead agent for each area of focus, running all the time, and a chief of staff agent that oversees them. Each lead manages its own sub-agents that write code, test it, chase reviews, and coordinate with team members.
Everything I need to decide or review comes into one prioritized queue, a simple local web app. Each product review includes screenshots and a video demo of the feature. I clear the queue in batches, mostly by voice and keyboard shortcuts. The leads also bring back ideas I hadn't considered.
Working from one queue, instead of switching between dozens of chats, has cut a lot of mental overhead. The system keeps learning my preferences and distilling my judgment into a "Brian brain," so its recommendations and first drafts get better before they reach me. The goal is fewer corrections per change.
Every change still goes through the same human review and security checks. It is eliminating tasks, not human judgment.
What an exciting time to push the frontier of productivity, especially as we build the economy for agents (agentic finance). We should all keep pushing in this direction.
A knowledge-driven framework for predicting single-cell responses for unprofiled drugs
nature.com/articles/s4225…
nature.com/articles/s4225…
Agree. The models are good enough. The bottleneck in my lab right now is jumping between Opus 5.5, GPT Astra/Sol and Kimi, then back to Opus 5.5, hoping not to get downgraded to 5.0 or 4.8 mid-task.
It’s also random and unreliable. Verifying my lab and going through Claude Science didn’t visibly help. Hope this gets fixed soon, it’s literally slowing down our work on better therapeutics.
It’s also random and unreliable. Verifying my lab and going through Claude Science didn’t visibly help. Hope this gets fixed soon, it’s literally slowing down our work on better therapeutics.
Opus 5.5 (via Code) is unusable with the most basic bio things. Just asking it to look at a published brain paper to include in a paper wiki switches to Opus 5.View quoted post on X
@lydiahallie this used to be fine until recently.
One of the biggest untapped opportunities for AI in biology may be locked inside lab notebooks.
Making them openly accessible, including failed experiments and details papers leave out, could so greatly improve AI models, deepen our understanding of biology, and make science more reproducible.
Making them openly accessible, including failed experiments and details papers leave out, could so greatly improve AI models, deepen our understanding of biology, and make science more reproducible.