Michal Sadowski (@sadowskimich)

Our paper showing that a broad class of scaling functions and endogenous treatment effects yield sign-consistent GxE is out @PLOSGenetics. doi.org/10.1371/journa…
We extend our theoretical results - e.g. defining the sign consistency rule when G and E are correlated. Take a look!

Michal Sadowski @sadowskimich Jul 19, 2025

New preprint. We show that a wide class of outcome transformations and endogenous treatment effects induce sign-consistent gene-environment interaction (GxE) effects. biorxiv.org/content/10.110…
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www.biorxiv.org The geometry of G × E: how scaling and endogenous treatment effects shape interaction direction Gene-environment interaction ( G × E ) studies hold promise for identifying genetic loci mediating the effects of environmental risk on disease. However, interpretation of G × E effects is often...

Michal Sadowski @sadowskimich Apr 19, 2025

We described the steps for estimating the heritability of drug response and identifying gene-drug interactions (the analyses we performed in cell.com/cell-genomics/…) in a detailed STAR protocol @STARProtocols.
star-protocols.cell.com/protocols/4164

Michal Sadowski @sadowskimich Dec 4, 2024

Our work using gene-environment interaction methods to study the genetics of drug response is now out in @CellGenomics. @CellPressNews
cell.com/cell-genomics/…

www.cell.com Characterizing the genetic architecture of drug response using gene-context interaction methods Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and...

Michal Sadowski @sadowskimich Mar 31, 2024

New preprint. In this paper we quantify heritability of drug response and identify involved genes by applying gene-environment interaction methods to biobank data. medrxiv.org/cgi/content/sh…
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Michal Sadowski

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