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Scheller Lab

@schellerlab

Neuroskeletal Biology Laboratory (NSBL) @WUSTLmed. Executive director @wustlcrm. President @ISBM_society. Nerves. Bones. Metabolism. Encouragement. 🔬🦴🧠❤️
Saint Louis, MO sites.wustl.edu/schellerlab Joined July 2019
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Scheller Lab @schellerlab
Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴

Full article here: lnkd.in/gH7eHv4r
Nature Metabolism Verified account @NatMetabolism Jan 9
A catecholamine-independent pathway controlling adaptive adipocyte lipolysis dlvr.it/TQF2Gk
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Scheller Lab @schellerlab
Many thanks to Dr. Affinati and Dr. Schwartz for their insightful commentary on our recent article in @NatMetabolism. 🙏 We are truly honored. Original manuscript link here: nature.com/articles/s4225…
www.nature.com A catecholamine-independent pathway controlling adaptive adipocyte lipolysis Nature Metabolism - Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.
Nature Metabolism Verified account @NatMetabolism Jan 9
Chewing the fat: a novel mechanism for lipolysis dlvr.it/TQF2QR
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Scheller Lab @schellerlab
Exciting work by @AriellaStudies that we were proud to be a part of!
Dr Singularity Verified account @Dr_Singularity Oct 13, 2025
Big anti aging news

Scientists Identify Core "Aging Genes" Shared Across Species. Silencing Them Extends Lifespan

Researchers publishing in Aging Cell have pinpointed a set of core genes that drive aging across multiple species, from humans to worms.

By analyzing 25 large gene expression datasets and testing the results in C. elegans, they found 6 key genes whose suppression extended lifespan by up to 15%.

These genes regulate immune activity, tissue maintenance, and DNA stability, and many are already linked to age related diseases like Alzheimer’s and macular degeneration.

The findings reveal universal aging mechanisms and new targets for anti aging therapies.
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