@scocmem
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www.nature.com Perioperative ivonescimab with or without chemotherapy in resectable non-small cell lung cancer: a... Nature Medicine - In a nonrandomized phase 2 trial, patients with resectable non-small cell lung cancer received perioperative ivonescimab as monotherapy or with chemotherapy, leading to... 🔥Perioperative ivonescimab ± chemo in resectable NSCLC
🆙 @NatureMedicine
🎯Primary endpoint met
🎯Cohort 2 (ivonescimab + chemo): MPR 70.1% (47/67), pCR 50.7% (34/67), RVT≤5% 97.9% (46/47)
🎯Cohort 1 (monotherapy) MPR 60.0% (6/10), pCR 30.0% (3/10), RVT≤5% 83.3% (5/6)
🎯All patients who underwent surgery achieved R0
🎯Grade ≥3 TRAEs 30.4%; no grade ≥3 hemorrhage or treatment-related death
🎙Dr. Xiaoliang Zhao
#LCSM @OncoAlert @Larvol
nature.com/articles/s4159…View quoted post on X
🇨🇳 Team China is sending a message: They're coming for the Uromigos World Cup! ⚽🏆
With Shanghai's Oriental Pearl Tower as their backdrop, they're tackling three of the biggest questions in ADC therapy: Selection, Overcoming Resistance, and Sequencing.
The race for the cup is heating up! 🔥
🎥 : @yao_zhu_sh & Xiaojie Bian | #UromigosLiveView quoted post on X
🚀 Could T-cell engagers open the next chapter in kidney cancer?
After disappointing phase III results with several IO/TKI/ HIF2a triplet strategies, we urgently need new mechanisms of action—not just more drugs!
Exciting phase I data for XmAb819, an ENPP3×CD3 bispecific T-cell engager in heavily pretreated ccRCC @montypal
🎯 Confirmed ORR: 45.5% (5/11) at the selected 400 µg/kg dose
🎯 35% ORR even after prior IO, VEGFR-TKI and HIF-2α inhibition
A fascinating approach: redirecting T cells directly against ENPP3-expressing tumor cells.
Could T-cell redirection become the next therapeutic pillar in RCC? 🔬
urotoday.com/conference-hig…
@OncoAlert @weoncologists @urotoday @Uromigos
@OncoAlert and Faculty: @DrChoueiri @tompowles1 @apolo_andrea @neerajaiims @montypal @Silke_Gillessen @AOmlin @brian_rini @PGrivasMDPhD @TiansterZhang @amerseburger @DrDanielHeng @HHammersMD @scocmem @AndreaNecchi @AmandaNizamMD @drenriquegrande @nataliagandur @AlbigesL @cdanicas @declangmurphy @seanmmcbride @shilpaonc @DrRanaMcKay @scserendipity1 @DrYukselUrun @ravikanesvaran @BraunMDPhD @EfstathiouEleni @mzugman @crisbergerot @Markuseckstein3View quoted post on X
