Sergio Acuna, MD, PhD

@seacm

Transplant/HPB Surgeon @UABSurgery | General Surgeon @UofTSurgery | Clinical Epidemiologist @ihpmeuoft

Birmingham, AL uab.edu/medicine/surge… Joined February 2010

1.8K Following 916 Followers 729 Posts

Latest posts 5

Exciting step forward for transplant in Alabama as we launch abdominal normothermic regional perfusion (A-NRP) at UAB in partnership with Legacy of Hope.

#OrganDonation #Transplantation #NRP #UABTransplant @UABSurgery

Sergio Acuna, MD, PhD @seacm Sep 29

UAB Abdominal Transplant at #ACSCC26!#UABTransplant #UABatACSCC2026 @UABSurgery

Sergio Acuna, MD, PhD @seacm Sep 5

Should perfusion be standard of care for DCD liver transplantation?

Our national analysis found better graft survival with either NRP or NMP than with rapid recovery and standard cold storage alone supporting broader adoption of both strategies.

Proud to share our work in @AnnalsofSurgery! @UABSurgery @mjonescarrMD

Annals of Surgery @AnnalsofSurgery Sep 4

In a national analysis of DCD liver transplantation, both normothermic regional perfusion and normothermic machine perfusion were associated with improved graft survival compared with super-rapid recovery and static cold storage. ovid.com/10.1097/SLA.00…

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Sergio Acuna, MD, PhD @seacm Mar 6

Elegant nationwide study linking impaired immune surveillance to colorectal carcinogenesis in transplant recipients.

Kidney transplant recipients show a selective increase in dMMR CRC, but not pMMR CRC, supporting the idea that neoantigen-rich tumors normally controlled by the immune system can progress under chronic immunosuppression.

amjtransplant.org/article/S1600-…

www.amjtransplant.org Risk of deficient mismatch repair colorectal cancer and precursors after kidney transplantation: A... Colorectal cancer (CRC) incidence rises posttransplant, though the mechanism remains unclear. We hypothesize that impaired immunosurveillance of kidney transplant recipients (KTRs) allows progression...

Sergio Acuna, MD, PhD @seacm Feb 21

Our new population-based cohort study of 5,178 SOTRs shows ↑ cumulative tacrolimus exposure is independently associated with ↑ post-transplant de novo malignancy.

Key findings:
• Linear exposure–risk relationship (no clear safety threshold)
• Present across all solid organ transplants
• Even modest increases (7 → 8.4 ng/mL over 1 year) ↑ cancer risk by ~9%

🔗 doi.org/10.1002/ijc.70…
#TransplantOncology #Immunosuppression #SOT